Ligand interactions of the cation-independent mannose 6-phosphate receptor
Journal of Biological Chemistry, 1989 The interaction of the bovine cation-independent mannose 6-phosphate receptor with a variety of phosphorylated ligands has been studied using equilibrium dialysis and immobilized receptor to measure ligand binding. The dissociation constants for mannose 6-phosphate, pentamannose phosphate, bovine testes beta-galactosidase, and a high mannose ...
P Y Tong +2 more
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The cation-dependent mannose 6-phophate receptor is S-palmitoylated and ubiquitinated for its trafficking in endosomes [PDF]
, 2009 The lysosomes form a crucial cellular compartment which degrades cellular wastes, and recycles the digested parts for the biosynthesis of new components.
Filippi, Bruno Guy Henri
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Harmonized tuning of nucleic acid and lectin binding properties with multivalent cyclodextrins for macrophage-selective gene delivery [PDF]
, 2015 Polycationic amphiphilic cyclodextrins (paCDs) have been shown to behave as efficient non-viral gene carriers paralleling the efficacy of commercial vectors towards a variety of cell lines.
Benito, Juan M. +6 more
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TIP47: A Cargo Selection Device for Mannose 6-Phosphate Receptor Trafficking [PDF]
Cell, 1998 Mannose 6-phosphate receptors (MPRs) transport newly synthesized lysosomal hydrolases from the Golgi to prelysosomes and then return to the Golgi for another round of transport. We have identified a 47 kDa protein (TIP47) that binds selectively to the cytoplasmic domains of cation-independent and cation-dependent MPRs.
Suzanne R. Pfeffer, Elva D Diaz
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Studies on mitogen regulated protein (proliferin) during murine development [PDF]
, 1988 Mitogen regulated protein/proliferin (MRP/PLF) is a glycoprotein with a significant percentage of positional identity in sequence with the prolactin-growth hormone family of proteins.
Mubaidin, Adnan M. D.
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Cellular & Molecular Biology LettersBackground The trafficking of cargoes from endosomes to the trans-Golgi network requires numerous sequential and coordinated steps. Cargoes are sorted into endosomal-derived carriers that are transported, tethered, and fused to the trans-Golgi network ...
Jérôme Gilleron +4 more
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The Structure and Biological Function of CREG
Frontiers in Cell and Developmental Biology, 2018 The cellular repressor of E1A-stimulated genes (CREG) is a 220 amino acid glycoprotein structurally similar to oxidoreductases. However, CREG does not have enzymatic activities because it cannot bind to the cofactor flavin mononucleotide.
Gaby Ghobrial +4 more
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Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice. [PDF]
PLoS ONE, 2013 Sorting nexin 5 (Snx5) has been posited to regulate the degradation of epidermal growth factor receptor and the retrograde trafficking of cation-independent mannose 6-phosphate receptor/insulin-like growth factor II receptor. Snx5 has also been suggested
Sun-Kyoung Im +6 more
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Mannose 6-phosphate receptor dependent secretion of lysosomal enzymes. [PDF]
The EMBO Journal, 1990 BHK and mouse L cells transfected with the cDNA for the human 46 kd mannose 6-phosphate receptor (MPR 46) secrete excessive amounts of newly synthesized mannose 6-phosphate containing polypeptides. The secretion is dependent on the amount, the recycling and the affinity for ligands of MPR 46. Incubation of transfected cells with antibodies blocking the
A. Hille +4 more
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Insulin-Like Growth Factor II (IGF-II) Is More Potent Than IGF-I in Stimulating Cortisol Secretion from Cultured Bovine Adrenocortical Cells: Interaction with the IGF-I Receptor and IGF-Binding Proteins [PDF]
, 1995 Although the stimulating effect of insulin-like growth factor I (IGF-I) on adrenal steroidogenesis has been well established, the role of IGF-II in the adult adrenal gland remains unknown.
Engelhardt, Dieter +3 more
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