Results 81 to 90 of about 65,862 (234)

Chlamydia trachomatis CT229 Subverts Rab GTPase-Dependent CCV Trafficking Pathways to Promote Chlamydial Infection

Cell Reports, 2019
Summary: Chlamydial infection requires the formation of a membrane-bound vacuole, termed the inclusion, that undergoes extensive interactions with select host organelles.
Robert Faris, Marlena Merling, Shelby E. Andersen, Cheryl A. Dooley, Ted Hackstadt, Mary M. Weber   +5 more
doaj  

Cryo-TEM structure of β-glucocerebrosidase in complex with its transporter LIMP-2

Nature Communications
Targeting proteins to their final cellular destination requires transport mechanisms and nearly all lysosomal enzymes reach the lysosome via the mannose-6-phosphate receptor pathway.
Jan Philipp Dobert, Jan-Hannes Schäfer, Thomas Dal Maso, Priyadarshini Ravindran, Dustin J. E. Huard, Eileen Socher, Lisa A. Schildmeyer, Raquel L. Lieberman, Wim Versées, Arne Moeller, Friederike Zunke, Philipp Arnold   +11 more
doaj   +1 more source

Engineered therapeutic antibodies with mannose 6-phosphate analogues as a tool to degrade extracellular proteins

Frontiers in Immunology
Inducing the degradation of pathological soluble antigens could be the key to greatly enhancing the efficacy of therapeutic monoclonal antibodies (mAbs), extensively used in the treatment of autoimmune and inflammatory disorders or cancer.
Morgane Daurat, Corentin Gauthier, Corentin Gauthier, Khaled El Cheikh, Lamiaa M. A. Ali, Lamiaa M. A. Ali, Elodie Morère, Elodie Morère, Nadir Bettache, Magali Gary-Bobo, Alain Morère, Marcel Garcia, Marie Maynadier, Ilaria Basile   +13 more
doaj   +1 more source

Renin and the IGFII/M6P Receptor System in Cardiac Biology

The Scientific World Journal, 2013
Nonenzymatic cardiac activities of renin are well described during the last years and contribute either to cardiac-specific effects of the renin-angiotensin-aldosterone-system (RAAS) or to the pharmacological effects of RAAS inhibition.
Jacqueline Heger, Klaus-Dieter Schlüter
doaj   +1 more source

Mechanism of cargo recognition by retromer-linked SNX-BAR proteins.

PLoS Biology, 2020
Endocytic recycling of internalized transmembrane proteins is essential for many important physiological processes. Recent studies have revealed that retromer-related Sorting Nexin family (SNX)-Bin/Amphiphysin/Rvs (BAR) proteins can directly recognize ...
Xin Yong, Lin Zhao, Wankun Deng, Hongbin Sun, Xue Zhou, Lejiao Mao, Wenfeng Hu, Xiaofei Shen, Qingxiang Sun, Daniel D Billadeau, Yu Xue, Da Jia   +11 more
doaj   +1 more source

Genome-wide RNAi Screen Reveals a Role for Multipass Membrane Proteins in Endosome-to-Golgi Retrieval

Cell Reports, 2014
Summary: Endosome-to-Golgi retrieval is an essential membrane trafficking pathway required for many important physiological processes and linked to neurodegenerative disease and infection by bacterial and viral pathogens.
Sophia Y. Breusegem, Matthew N.J. Seaman   +1 more
doaj  

Identification of mannose 6-phosphate receptors in rabbit alveolar macrophages.

Journal of Biological Chemistry, 1984
Mannose 6-phosphate is an important recognition site involved in transport of newly synthesized lysosomal enzymes from the endoplasmic reticulum to lysosomes. The current study is the first demonstration of functional mannose phosphate receptors in macrophages.
P D Stahl, Hudson H. Freeze, V L Shepherd, A L Miller   +3 more
openaire   +3 more sources

BMN 250, a fusion of lysosomal alpha-N-acetylglucosaminidase with IGF2, exhibits different patterns of cellular uptake into critical cell types of Sanfilippo syndrome B disease pathogenesis.

PLoS ONE, 2019
Sanfilippo syndrome type B (Sanfilippo B; Mucopolysaccharidosis type IIIB) occurs due to genetic deficiency of lysosomal alpha-N-acetylglucosaminidase (NAGLU) and subsequent lysosomal accumulation of heparan sulfate (HS), which coincides with devastating
Gouri Yogalingam, Amanda R Luu, Heather Prill, Melanie J Lo, Bryan Yip, John Holtzinger, Terri Christianson, Mika Aoyagi-Scharber, Roger Lawrence, Brett E Crawford, Jonathan H LeBowitz   +10 more
doaj   +1 more source

Titan cell production in Cryptococcus neoformans reshapes the cell wall and capsule composition during infection [PDF]

, 2018
This work was supported by the National Institutes of Health (R01AI080275 and R21AI22352), the NIH Fogarty International Center (R25TW009345), the University of Minnesota Center for Translational Science Institute (UL1TR000114), Wellcome Trust (086827 ...
Gow, Neil A R, Lee, Keunsook, Mukaremera, Liliane, Nielsen, Kirsten, Wagener, Jeanette, Wiesner, D. L.   +5 more
core   +1 more source

Assembly of the mannose-6-phosphate receptor into reconstituted clathrin coats. [PDF]

The EMBO Journal, 1985
In ionic conditions in which clathrin coats are stable, the mannose-6-phosphate receptor associates with the 100-kd/50-kd coat complexes purified from bullock brain coated vesicles. These aggregates exist as striking spherical structures of 300-1000 A diameter.
openaire   +3 more sources