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Effect of Age and Age‐Defined Menopausal Status on Linaclotide Efficacy and Safety in Adults With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic Constipation: Post Hoc Analyses of Phase 2b/3 Studies

open access: yesNeurogastroenterology &Motility, Volume 38, Issue 9, September 2026.
A post hoc pooled analysis of eight phase 2b/3 trials showed that linaclotide improved bowel and abdominal symptoms and was associated with a shorter time to response than placebo in adults with IBS‐C or CIC, irrespective of age or age‐defined menopausal status.
Lin Chang   +9 more
wiley   +1 more source

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