Results 101 to 110 of about 101,522 (253)

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Variation in forest root image annotation by experts, novices, and AI

Plant Methods
Background The manual study of root dynamics using images requires huge investments of time and resources and is prone to previously poorly quantified annotator bias.
Grace Handy, Imogen Carter, A. Rob Mackenzie, Adriane Esquivel-Muelbert, Abraham George Smith, Daniela Yaffar, Joanne Childs, Marie Arnaud   +7 more
doaj   +1 more source

Improved Manual Annotation of EEG Signals through Convolutional Neural Network Guidance. [PDF]

eNeuro, 2022
Diachenko M, Houtman SJ, Juarez-Martinez EL, Ramautar JR, Weiler R, Mansvelder HD, Bruining H, Bloem P, Linkenkaer-Hansen K.   +8 more
europepmc   +1 more source

Annotating Football Matches: Influence of the Source Medium on Manual Annotation.

, 2012
In this paper, we present an annotation campaign of football (soccer) matches, from a heterogeneous text corpus of both match minutes and video commentary transcripts, in French. The data, annotations and evaluation process are detailed, and the quality of the annotated corpus is discussed.
Fort, Karen, Claveau, Vincent
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Refining manual annotation effort of acoustic data to estimate bird species richness and composition: The role of duration, intensity, and time. [PDF]

Ecol Evol, 2022
Shaw T, Schönamsgruber SR, Cordeiro Pereira JM, Mikusiński G.   +3 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Manual annotation of Drosophila genes: a Genomics Education Partnership protocol. [PDF]

F1000Res, 2022
Rele CP, Sandlin KM, Leung W, Reed LK.
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source