Results 41 to 50 of about 367,695 (283)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
La literatura en la enseñanza de ELE: un trayecto desde los inicios hasta el siglo XXI
Círculo de Lingüística Aplicada a la Comunicación, 2021 La literatura ha experimentado importantes altibajos en lo que se refiere a su presencia y protagonismo en los métodos y enfoques más relevantes adoptados en el proceso de enseñanza y aprendizaje de idiomas desde sus inicios hasta la época actual.
Jacinto González Cobas
doaj +1 more source
Competencia discursiva escrita en los niveles avanzado (B2) y dominio (C1): la unidad textual en los manuales de ELE [PDF]
, 2010 Este trabajo muestra dos perspectivas complementarias desde las que suele afrontarse la enseñanza de la competencia discursiva escrita en los manuales de ELE: la gramatical y la comunicativa.
Llamas-Saíz, C. (Carmen)
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Religión y Best Sellers: superar una disociación para entender la espiritualidad contemporánea [PDF]
, 2017 Diversos indicadores evidencian la expansión de la venta y consumo de libros que, en términos generales son considerados “de autoayuda”, “superación personal”, y que nominaré como literatura espiritual contemporánea o masiva1.
Seman, Pablo Federico
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
¿Ha cambiado el patrón de consumo alimentario de la población española del año 2006 al 2011 en plena crisis económica? [PDF]
, 2014 Antecedentes/Objetivos: El consumo de alimentos es un indicador que mide calidad de la dieta y estado nutricional. El consumo está influido directamente por la estructura de precios relativos a los alimentos.
Fernández-Sáez, José +3 more
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Manual Training and Manual Labor [PDF]
The Elementary School Teacher, 1904 THE march of manual training in the educational world is rivaled by the retreat of manual labor in the industrial world. At first glance the general situation seems to be something of an anomaly. The tremendous development of machinery and applied science in the industrial world has crowded in between the brain and the hand, feeding on both ...
openaire +1 more source