Results 41 to 50 of about 35,682 (304)
LOS VERBOS PSICOLÓGICOS EN LOS MANUALES DE ELE: UN ANÁLISIS COMUNICATIVO-COGNITIVO
, 2020 Las Gramáticas Cognitiva y Operativa como enfoques centrados en la enseñanza de lenguas defienden el imperturbable vínculo forma-significado y le confieren así a la gramática el valor semántico que merece. Sin embargo, su aplicación en el aula de Español
Martín Gascón, Beatriz +1 more
core +1 more source
Círculo de Lingüística Aplicada a la Comunicación, 2023 En esta introducción, expondremos el objetivo fundamental de la investigación desarrollada en los artículos que integran este monográfico, a saber: analizar las relaciones que existen entre la teoría lingüística, por un lado, y la enseñanza-aprendizaje ...
María Martínez-Atienza de Dios
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Las consignas de trabajo en manuales de Historia [PDF]
, 2014 En la actualidad son frecuentes las quejas de docentes sobre las dificultades que presentan sus alumnos para comprender los textos que deben leer. Lógicamente, este es un problema que repercute claramente en los procesos de enseñanza de disciplinas ...
Santos La Rosa, Mariano
core
, 1900 Probablemente editado nas primeiras décadas do ...
Asensio, Josef, 1759-ca. 1820
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Manuales escolares e identidades nacionales
, 2020 El interés de los investigadores por los manuales escolares es relativamente reciente aunque ya bien afianzado, e indica una renovación y una inflexión indudable en las investigaciones llevadas a cabo en el marco de la historia de la educación. Dentro de
Guereña, Jean-Louis
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source