Results 51 to 60 of about 367,695 (283)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Enfoques metodológicos recientes en los manuales de historia del pensamiento económico [PDF]
, 1989 Este documento de trabajo tan sólo realiza una posible agrupación de los distintos métodos de enfocar y abordar el estudio e investigación de la historia del pensamiento económico, al tiempo que orienta acerca de los distintos manuales que han salido al ...
Méndez Ibisate, Fernando
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La enseñanza española de la historia y su dimensión Iberoamericana [PDF]
, 2012 La presencia de los países iberoamericanos es una cuestión que ha estado permanentemente asegurada en los libros de texto de la educación secundaria española desde la implantación del sistema educativo liberal, a mediados del siglo XIX, hasta la ...
Valls Montés, Rafael
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Sistema Contable en la Empresa Agropecuaria ‘‘Los Potrerillos’’ S.A del municipio de Jinotega, en el I semestre del año 2015. [PDF]
, 2016 En el presente Seminario de Graduación abordamos el Sistema Contable de las empresas de Matagalpa y Jinotega, con el fin de analizar el Sistema Contable de la Empresa Agropecuaria “Los Potrerillos S.A.” en el municipio de Jinotega en el I semestre del ...
Campos Meza, Iranel Stephan +1 more
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Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source