Results 31 to 40 of about 11,850 (257)

Methodological aspects of school education improvement in Ukraine (the second half of the XIX – early XX centuries)

Науковий Вісник Південноукраїнського Національного Педагогічного Університету імені К. Д. Ушинського, 2022
The process of methodological search in the field of school education is continuous and is based on the analysis of historical experience and modern requirements of society to the level of school education. Under such conditions, a retrospective study of
Vykhrushch Nataliya
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Academician Ivan Stepanovich Kolesnikov (1901–1985) (on the 120^th anniversary of the birth)

Вестник хирургии имени И.И. Грекова, 2022
Received 25.02.2022; accepted 09.03.2022 An outstanding Soviet surgeon, one of the founders of military field surgery – participant in six wars, Hero of Socialist Labor (1976), academician of the USSR Academy of Medical Sciences (1971), Honored Scientist
I. I. Dzidzava, B. N. Kotiv, A. A. Kurygin, V. I. Iontsev, O. V. Barinov, I. V. Dmitrochenko   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

To know diverse manner of weeds: the development of weed identification manuals in early modern England and their influence on North American guides

Weed Technology
The history of weed science as a discipline has been a topic of interest for decades, but it is rare for researchers to consider publications prior to the 19th century or that were not focused on North America.
Alice C. Wolff, Antonio DiTommaso
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Letter-writing manuals and the evolution of requests markers in the eighteenth century

Revista de Lenguas para Fines Específicos, 2015
In eighteenth century England the middle classes were looking for assistance guides to help them to move upwards in society. Among those help books we find letter-writing manuals, a very popular text-type in the Late Modern English period, which provided
Fátima Faya Cerqueiro
doaj  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source