Results 91 to 100 of about 2,561,996 (344)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Human Factors and Ergonomics in Industry 5.0—A Systematic Literature Review
Applied SciencesHuman-centricity, sustainability, and resilience are the core pillars of the Industry 5.0 concept. The human-centric perspective emphasizes the development of socio-technical systems designed to enhance human health, safety, and well-being while ...
Maja Trstenjak +3 more
doaj +1 more source
From Immigrants to Robots: The Changing Locus of Substitutes for Workers
RSF: The Russell Sage Foundation Journal of the Social Sciences, 2019 Using numbers of industrial robots shipped to primarily manufacturing industries as a supply shock to an industry labor market, we estimate that an additional robot reduces employment by roughly two to three workers overall and by three to four workers ...
George J. Borjas, Richard B. Freeman
doaj +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Application of Bayesian Optimization in Gripper Design for Effective Grasping
IEEE AccessDespite many recent technological advancements, grasping remains a challenging open problem in robotic manipulation. In contrast with most research which focuses equipping grippers with varying degree of intelligence, we approach grasping from a gripper ...
Marco Todescato +2 more
doaj +1 more source