Results 161 to 170 of about 2,561,996 (344)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Exploration of environmental governance in manufacturing enterprises under the central environmental supervision mechanism in China: a multidimensional empirical study based on double difference analysis. [PDF]

Carbon Balance Manag
Liu H, Li S, Zhao H.
europepmc   +1 more source

Additive Manufacturing of Titanium Alloys-A Review

, 2021
M. B. Kiran
openalex   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Emerging Chemical and Biological Materials Technologies in the Extraplanetary Environment. [PDF]

Nanomicro Lett
Jiang Q, Wang B, Cheng Y, Wang Y, Zhao H, Lu Y.   +5 more
europepmc   +1 more source

Advances in Manufacturing Science and Engineering

, 2013
Xiang Hua Liu, Kai Feng Zhang, Ming Zhe Li   +2 more
openalex   +1 more source

Geographic Concentration in U.S. Manufacturing Industries: A Dartboard Approach

Journal of Political Economy, 1994
Glenn Ellison, E. Glaeser
semanticscholar   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Industrializing CAR-T cell therapy: impact of automation on cost and space efficiency of manufacturing facilities. [PDF]

Front Bioeng Biotechnol
Weltin AL, De Graaf Y, Goudarzi A, Müller M, Herbst L, Nießing B, Vrijhoef HJM, Schmitt RH.   +7 more
europepmc   +1 more source

Application of Voronoi Tessellation to the Additive Manufacturing of Thermal Barriers of Irregular Porous Materials—Experimental Determination of Thermal Properties [PDF]

Beata Anwajler
openalex   +1 more source