Results 51 to 60 of about 1,271,617 (289)

Effect of advanced manufacturing technology, concurrent engineering of product design, and supply chain performance of manufacturing companies [PDF]

open access: yes, 2015
As competition shifts away between competitors to supply chains, simultaneous sharing of technical expertise on product design is key to manufacturing success.
Abd Rahman, Azmawani   +2 more
core   +3 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

The development of the application of artificial intelligence in production engineering: One glance [PDF]

open access: yesTehnika
Artificial intelligence (AI) has today become the most important element of the Industry 4.0 model in application, and on the way to building a smart factory.
Majstorović Vidosav D.
doaj   +1 more source

Engineering Workflow: The Process in Product Data Technology [PDF]

open access: yes, 2000
The prevailing paradigm for enterprises in the new decade is undoubtedly speed. This enterprise view is driven by the availability of e-business technology that enables new forms of collaboration between companies.
Bijwaard, D.J.A.   +2 more
core   +1 more source

Synthetic biology—putting engineering into biology [PDF]

open access: yes, 2006
Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we ...
Heinemann, Matthias,, Panke, Sven,
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Manufacturing Systems Operations and Engineering

open access: yesApplied Sciences
Although the issues of design, organization, and management of industrial systems have been known in the literature for many years, the beginning of the 21st century, as a consequence of market changes and unprecedented technological development ...
Arkadiusz Gola   +2 more
doaj   +1 more source

Engineering Meets Manufacturing [PDF]

open access: yesMechanical Engineering, 2007
This article discusses the future of software that links engineering and manufacturing. Companies are seeking a natural link between engineering and manufacturing, even if some aspects of it may be restricted. According to experts, giving manufacturers direct access to that design information would help them isolate potential manufacturing problems ...
openaire   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

SLASSY—An Assistance System for Performing Design for Manufacturing in Sheet-Bulk Metal Forming: Architecture and Self-Learning Aspects

open access: yesAI, 2021
Substantial efforts have been made to integrate manufacturing- and design-relevant knowledge into product development processes. A common approach is to provide the relevant knowledge to the design engineers using a knowledge-based system (KBS) that, in ...
Christopher Sauer   +4 more
doaj   +1 more source

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