Results 71 to 80 of about 1,209,744 (339)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Web-based CBR (case-based reasoning) as a tool with the application to tooling selection [PDF]

, 2005
Over the past few years, manufacturing companies have had to deal with an increasing demand for feature-rich products at low costs. The pressures exerted on their existing manufacturing processes have lead manufacturers to investigate internet-based ...
Aamodt, Dereli, J. Toussaint, K. Cheng, McMullen, Ong, Pomerol, Qiu, Smith   +8 more
core   +2 more sources

A Comprehensive Decision-Making Approach for Strategic Product Module Planning in Mass Customization

Mathematics
This paper explores the integrated optimization of complex coupled industrial manufacturing systems and production strategies based on user customization needs. Two optimization metrics are considered: one is whether the production process of engineering
Shuo-Fang Liu, Shi-Yu Wang, Hsueh-Hung Tung   +2 more
doaj   +1 more source

Additive Manufacturing of Hydrogels in Tissue Engineering [PDF]

Journal of Chemistry Letters
Systematically review the development of 3D printing, describe the area of 3D printing hydrogel research, and describe the development of 3D printing hydrogel.
Md. Shyeed, Md. Kamrul Hasan, Mst Khadiza Khatun, Khan Rajib Hossain, Danli Hu, Xiaolong Wang   +5 more
doaj   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

The use of simulated games in an undergraduate course manufacturing processes [PDF]

, 2009
Simulation games bring the real engineering situation into class room. They are ideally suited to situations where the size and cost of some systems cannot be replicated in educational institutions, e.g.
Pather, Selvan, Wang, Hao
core  

Set-Based Concurrent Engineering process within the LeanPPD environment [PDF]

, 2011
This paper presents a newly defined set-based concurrent engineering process, which the authors believe addresses some of the key challenges faced by engineering enterprises in the 21st century. The main principles of Set-Based Concurrent Engineering (
Al-Ashaab, Ahmed, Doultsinou, Athanasia, Ewers, Paul, Khan, Muhammad, Shehab, Essam, Sulowski, Robert   +5 more
core   +1 more source

Additive Manufacturing and Chemical Engineering: Looking for Synergies from a Bibliometric Study

Applied Sciences
Additive manufacturing must be highlighted as an innovative technology with the capacity to produce objects with complex and customized geometries using a diverse range of raw materials.
Rodrigo Estévez, Esteban Quijada-Maldonado, Julio Romero, Ricardo Abejón   +3 more
doaj   +1 more source