Results 81 to 90 of about 4,830,203 (376)

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Web-based CBR (case-based reasoning) as a tool with the application to tooling selection [PDF]

, 2005
Over the past few years, manufacturing companies have had to deal with an increasing demand for feature-rich products at low costs. The pressures exerted on their existing manufacturing processes have lead manufacturers to investigate internet-based ...
Aamodt, Dereli, J. Toussaint, K. Cheng, McMullen, Ong, Pomerol, Qiu, Smith   +8 more
core   +2 more sources

A Comprehensive Decision-Making Approach for Strategic Product Module Planning in Mass Customization

Mathematics
This paper explores the integrated optimization of complex coupled industrial manufacturing systems and production strategies based on user customization needs. Two optimization metrics are considered: one is whether the production process of engineering
Shuo-Fang Liu, Shi-Yu Wang, Hsueh-Hung Tung   +2 more
doaj   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

The use of simulated games in an undergraduate course manufacturing processes [PDF]

, 2009
Simulation games bring the real engineering situation into class room. They are ideally suited to situations where the size and cost of some systems cannot be replicated in educational institutions, e.g.
Pather, Selvan, Wang, Hao
core  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Additive Manufacturing and Chemical Engineering: Looking for Synergies from a Bibliometric Study

Applied Sciences
Additive manufacturing must be highlighted as an innovative technology with the capacity to produce objects with complex and customized geometries using a diverse range of raw materials.
Rodrigo Estévez, Esteban Quijada-Maldonado, Julio Romero, Ricardo Abejón   +3 more
doaj   +1 more source

Bibliometric analysis of model-based systems engineering in advanced manufacturing [PDF]

Journal of Intelligent Manufacturing and Special Equipment
Purpose – Model-based systems engineering (MBSE) is an important approach for the transforming process from “document-centered” to “model centered” systems engineering mode in equipment development, which can effectively shorten the equipment development
Jinzhi Lu, Yihui Gong, Guoxin Wang, Yan Yan   +3 more
doaj   +1 more source

The adoption and use of Through-life Engineering Services within UK Manufacturing Organisations [PDF]

, 2014
Manufacturing organisations seek ever more innovative approaches in order to maintain and improve their competitive position within the global market. One such initiative that is gaining significance is ‘through-life engineering services’.
Phillips, Paul, Redding, Louis E., Roy, Rajkumar, Shaw, Andrew, Tiwari, Ashutosh   +4 more
core   +1 more source