Results 71 to 80 of about 2,775,388 (305)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

DETECTION OF PROCESS ERRORS OF ADDITIVE MANUFACTURING

open access: yesMM Science Journal
Additive manufacturing has the potential to revolutionize the production of complex and adapted parts, but is prone to manufacturing errors, ranging from minor inaccuracies and mechanical failures to complete failures associated with the production of rejects.
PETER GABSTUR   +2 more
openaire   +1 more source

Jeffrey Manufacturing Company Aerial Views

open access: yes, 1905
Three aerial views illustrate the growth of the Jeffrey Manufacturing Company plant in Columbus, Ohio ...
The Jeffrey Manufacturing Company (Photographer)
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Persistence-Based Absolute Relative Error for Alarm-Centric Monitoring Under Low-Frequency Manufacturing

open access: yesMathematics
Manufacturing condition monitoring in low-frequency sensing environments presents significant challenges for traditional anomaly detection methods, which depend on dense temporal observations or instantaneous thresholding.
Jinwoo Song, Heung Soo Kim
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Jeffrey Manufacturing Company library photograph

open access: yes, 1940
Photograph of the library of the Jeffrey Manufacturing Company, Columbus, Ohio, ca. 1946. This photo is of the inside of the library.
Jeffrey Manufacturing Company
core  

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

Layout Optimization of Multi-Robot Manufacturing Processing Systems: Applications in Directed Energy Deposition–Arc Additive Manufacturing and Jig-Less Welding

open access: yesMachines
Layout design is the process in which industrial robots and other manufacturing components are positioned within a manufacturing system so that the intended operations can be handled appropriately.
Michail Aggelos Terzakis   +6 more
doaj   +1 more source

Jeffrey Manufacturing Company Structural Shop

open access: yes, 1905
This is a 1905 photograph of the structural shop built by the Jeffrey Manufacturing Company of Columbus, Ohio.
The Jeffrey Manufacturing Company (Photographer)
core  

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