Results 81 to 90 of about 816,445 (307)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Layout Optimization of Multi-Robot Manufacturing Processing Systems: Applications in Directed Energy Deposition–Arc Additive Manufacturing and Jig-Less Welding

Machines
Layout design is the process in which industrial robots and other manufacturing components are positioned within a manufacturing system so that the intended operations can be handled appropriately.
Michail Aggelos Terzakis, Christos Papaioannou, Iñaki Sainz, Jonatan Rodriguez Vazquez, Panagiotis Lagios, Enrique Gil Illescas, Panagiotis Stavropoulos   +6 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Vibration Characteristic Analysis of Differential Reducer Gear Pair Considering Random Manufacturing Error

Jixie chuandong, 2021
In order to study the influence of random manufacturing error on the vibration characteristics of differential gear drive system of a new energy vehicle，the Lagrange energy method is used to establish the bending torsion shaft coupling vibration dynamic ...
Lingsong Fan, Aihua Ren, Zhangdong Sun, Nan Zhang   +3 more
doaj  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Economic tolerance design of the P2 raceway based on the quasi-static model of aerospace ball bearings

Scientific Reports
This study focused on designing the raceway tolerance of high-precision rolling bearings. After the tolerance error equivalence relationship is defined, the application of the rolling bearing error equalization effect in tolerance design is studied ...
Zhou Chang, Lai Hu, Wenhan Cao
doaj   +1 more source

Agglomeration within and between regions: Two econometric based indicators [PDF]

We propose two indexes to measure the agglomeration forces acting within and between different regions. Unlike the existing measures of agglomeration, our model-based indexes allow for simultaneous treatment of both aspects.
Marcello Pagnini, Valter Di Giacinto
core  

Application of Visual Clustering Properties of Self Organizing Map in Machine-part Cell Formation

, 2012
Cellular manufacturing (CM) is an approach that includes both flexibility of job shops and high production rate of flow lines. Although CM provides many benefits in reducing throughput times, setup times, work-in-process inventories but the design of CM ...
Chattopadhyay, Manojit, Dan, Pranab K., Majumdar, Sitanath   +2 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

An Inverse Analysis Method of Transmission Accuracy of Harmonic Reducer based on Multi-factor Coupling

Jixie chuandong, 2021
Transmission error of harmonic reducer is coupled by eccentric vectors such as geometric eccentricity and motion eccentricity during parts machining and assembly， and has frequency domain characteristics.
Linna Zhao, Long Wang, Jin Fang, Deyong Li, Kai Wang, Haiyue Li, Huanbin Xu, Guangqiang Xing, Yue Zhang, Ning Wang   +9 more
doaj