Results 61 to 70 of about 1,574,435 (263)
Chinese Journal of Mechanical Engineering, 2022 Precision grinding is a key process for realizing the use of large-aperture aspherical optical elements in laser nuclear fusion devices, large-aperture astronomical telescopes, and high-resolution space cameras.
Changsheng Li +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Virtual and Physical Prototyping, 2020 Biodegradable scaffolds are considered as the key component of tissue engineering which serve as temporary structural supports for tissue regeneration. The mechanical/biological properties of artificial synthetic polymeric scaffolds are highly dependent ...
Zijie Meng +4 more
doaj +1 more source
Rapid manufacturing as a tool for agile manufacturing: applications and implementation perspectives [PDF]
, 2006 Manufacturing engineers and technologists around the globe are already well familiar with manufacturing methodologies and systems developments in the last part of the twentieth century.
Bateman, RJ, Cheng, K
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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
An Empirical study on the competitiveness and innovation in four sectors of the Turkish manufacturing industry [PDF]
, 2007 In this paper, we report on some of the results of the Innovations in Manufacturing Industries in Turkey Study (IMITS). This study is an empirical investigation into the innovation performance and competitive strategies of manufacturing firms in Turkey ...
Bulut, Cagri +7 more
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Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
VALIDATING COOPERATIVE SYSTEMS SIMULATION AND REMODELING FOR PUMP COVER DESIGN AND MANUFACTURING IN A VIRTUAL ENTERPRISE [PDF]
In order to integrate the manufacturing systems in virtual environment some changes must be made in manufacturing systems architecture. To support this environment, the basic infrastructure for the enterprise must to consider two main modules: The ...
Cicerone-Laurentiu POPA +1 more
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