Results 61 to 70 of about 51,831 (260)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Historiography and Hagiographic Texts

open access: yesAnnali di Ca’ Foscari: Serie Orientale, 2016
The present paper is part of a larger project promoted by the University RomaTre on translations of Greek Patristic Texts (2nd-6th century CE) in the Latin and Syriac sources, between the 3rd and the 8th century CE.
Tavolieri, Claudia
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

La transmission française de la méthode de débourrage de Jordanus Rufus (xiiie-xvie siècles)

open access: yesArts et Savoirs
The only original method for breaking-in horses in Western Europe in the late medieval period is found in Jordanus Rufus’ De medicina equorum (c. 1250). Seven Middle French translations of this text exist, dating from the 13th to the 16th centuries.
Camille Vo Van Qui
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Federica Buttò, Le « Tristan en prose » du ms. BnF français 756 : texte et étude

open access: yesPerspectives Médiévales
Sixteen years after the last publication of a volume of the Tristan en prose (2007), this work completes this edition based on the manuscript Paris, Bibliothèque nationale de France, français 757, by making available the first half of the prose romance ...
Federica Buttò
doaj   +1 more source

La tradizione di Peire d’Alvernhe e altri appunti

open access: yesCarte Romanze, 2014
L’articolo si propone di studiare i canali attraverso i quali l’opera di Peire d’Alvernhe ha raggiunto l’età di compilazione dei canzonieri provenzali.
Giorgio Barachini
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

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