Results 61 to 70 of about 1,535,370 (308)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
St. Gallen, Stiftsbibliothek, Cod. Sang. 603 : Composite manuscript
Collection manuscript, 15th century, from the Dominican convent of St. Katharina in St. Gall. This German-language manuscript is made up of five fascicles and contains a treatise on the Passion of Christ (“Vierzig Myrrhenbüschel vom Leiden Christi‟): the
Sattler, Regina +3 more
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Basel, Universitätsbibliothek, C I 1 : Digestum vetus cum glossa
This legal manuscript was owned by the Basel jurist Arnold Zum Luft (1453-1517). The manuscript was produced in Bologna in the second half of the 13th century and contains the Digestum vetus, the first part of the tradition regarding existing laws ...
Zum Luft, Arnold +2 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Solothurn, Zentralbibliothek, Cod. S 392 : Composite manuscript with art technology recipes
This substantial composite manuscript contains approximately 2.000 recipes and instructions, principally from art technology, but also other medical, culinary and alchemistic ones.
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Basel, Universitätsbibliothek, B X 12 : Composite Manuscript
This composite manuscript is from the library of the Carthusian Monastery of Basel; it contains the first part of the Orationes et meditationes de vita Christi by the mystic Thomas à Kempis (1379-1471), one of the most important representatives of the ...
Heinrich Arnoldi +5 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Basel, Universitätsbibliothek, B X 8 : Composite manuscript with material for sermons
This manuscript for regular use consists of four parts; it contains material for preparing sermons, including a register of sermon topics, an extensive corpus of legends and more than 100 exempla.
Jakob, von Vitry +5 more
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