Results 101 to 110 of about 7,752,729 (310)

Accelerating the SCE-UA Global Optimization Method Based on Multi-Core CPU and Many-Core GPU

open access: yesAdvances in Meteorology, 2016
The famous global optimization SCE-UA method, which has been widely used in the field of environmental model parameter calibration, is an effective and robust method.
Guangyuan Kan   +6 more
doaj   +1 more source

Element 6 Chairs and Course List Core General Education Assessment, 2018-2019

open access: yes, 2019
The Chairs and Course List for Element 6 - Natural Science as part of the institution’s ongoing general education Core assessment ...
Undergraduate Core Oversight Committee, Wright State University
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Toward Earth system modeling with resolved clouds and ocean submesoscales on heterogeneous many-core HPCs. [PDF]

open access: yesNatl Sci Rev, 2023
Zhang S   +38 more
europepmc   +1 more source

Many-Task Computing on Many-Core Architectures

open access: yesScalable Computing: Practice and Experience, 2016
Many-Task Computing (MTC) is a common scenario for multiple parallel systems, such as cluster, grids, cloud and supercomputers, but it is not so popular in shared memory parallel processors. In this sense and given the spectacular growth in performance and in number of cores integrated in many-core architectures, the study of MTC on such architectures ...
Pedro Valero-Lara   +5 more
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

High-Level Support for Pipeline Parallelism on Many-Core Architectures

open access: yes, 2012
International audienceWith the increasing architectural diversity of many-core architectures the challenges of parallel programming and code portability will sharply rise.
Thibault, Samuel   +11 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

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