Results 151 to 160 of about 1,043,830 (367)

Global analysis of protein phosphorylation in yeast [PDF]

, 2005
Protein phosphorylation is estimated to affect 30% of the proteome and is a major regulatory mechanism that controls many basic cellular processes.
Mah, Angie S., Ptacek, Jason
core   +1 more source

Role of calcium in the expression of MAP kinase kinases (MKKs) and MAP kinases in tomato flower abscission

AFRICAN JOURNAL OF BIOTECHNOLOGY, 2012
The mitogen activated protein kinase (MAPK) cascade is an important intracellular signaling module that functions as a convergent point for crosstalk during stress signaling. In this study, we constructed a phylogenetic tree for MAP kinase kinases (MKKs) and MAP kinases (MPKs) in Arabidopsis and Lycopersicon esculentum (tomato) and found that ...
Hong Li, Shuangshuang Lv, Song Gao, Xiaoxi Guan, Tao Xu, Tianlai Li, Jinhong Li   +6 more
openaire   +3 more sources

Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF. [PDF]

, 1991
Yukiko Gotoh, Kenji Moriyama, Shinji Matsuda, Eiichi Okumura, Takeo Kishimoto, Hiroshi Kawasaki, Kazuo Suzuki, Ichiro Yahara, Eiko Sakai, Eisuke Nishida   +9 more
openalex   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Molecular subtyping of cancer and nomination of kinase candidates for inhibition with phosphoproteomics: Reanalysis of CPTAC ovarian cancerResearch in context

EBioMedicine, 2019
Background: Molecular subtyping of cancer aimed to predict patient overall survival (OS) and nominate drug targets for patient treatments is central to precision oncology.
Mengsha Tong, Chunyu Yu, Dongdong Zhan, Ming Zhang, Bei Zhen, Weimin Zhu, Yi Wang, Congying Wu, Fuchu He, Jun Qin, Tingting Li   +10 more
doaj  

Activation of the cellular mitogen-activated protein kinase pathways ERK, P38 and JNK during Toxoplasma gondii invasion

Parasite, 2003
Host cell invasion is essential for the pathogenicity of the obligate intracellular protozoan parasite Toxoplasma gondii. In the present study, we evaluated the ability of T.
Valère A., Garnotel R., Villena I., Guenounou M., Pinon J.M., Aubert D.   +5 more
doaj   +1 more source

MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase. [PDF]

, 1992
Sara Nakielny, Philip Cohen, Jie Wu, Thomas W. Sturgill   +3 more
openalex   +1 more source

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway. [PDF]

, 1994
R Ben-Levy, Hugh F. Paterson, Chris Marshall, Yosef Yarden   +3 more
openalex   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source