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MAP kinase kinase kinases and innate immunity

Trends in Immunology, 2006
Toll-like receptors, which respond to invariant microbial molecules, and receptors for the proinflammatory cytokines tumour necrosis factor and interleukin-1 are crucial for initiation and regulation of innate immune responses. These receptors activate each of the major mitogen-activated protein (MAP) kinase subtypes, extracellular signal-regulated ...
Antony, Symons   +2 more
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MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

Current Opinion in Genetics & Development, 1994
Signal transduction pathways that respond to external signals through the MAP kinase family of protein kinases are involved in diverse responses in eukaryotic cells. MAP kinases are one element in a series of kinases that serve to connect the plasma membrane with cytoplasmic and nuclear events. MAP kinases have the unusual feature that their activation
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Raf-1 activates MAP kinase-kinase

Nature, 1992
The normal cellular homologue of the acutely transforming oncogene v-raf is c-raf-1, which encodes a serine/threonine protein kinase that is activated by many extracellular stimuli. The physiological substrates of the protein c-Raf-1 are unknown.
J M, Kyriakis   +6 more
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Plant MAP kinase kinase kinases structure, classification and evolution

Gene, 1999
The increasing number of reports describing plant MAP kinase signalling components reflects the cardinal role that MAP kinase pathways are likely to play during plant growth and development. Relationship and structural analyses of plant MAP kinase kinase kinase related cDNAs and genes established, on one hand, the PMEKKs, which may be distinguished ...
S, Jouannic   +5 more
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MAP Kinases

Chemical Reviews, 2001
Z, Chen   +8 more
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[MAP kinase kinase/MAP kinase cascade].

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1993
Y, Gotoh, E, Nishida
openaire   +1 more source

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