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Cryo-EM structure of histidyl-tRNA synthetase-like domain reveals activating crossed helices at the core of GCN2. [PDF]
Solorio-Kirpichyan K+5 more
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Global landscape of protein phosphorylation during plant regeneration initiation in cotton (Gossypium hirsutum L.). [PDF]
Guo H+11 more
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Luteolin targets MKK4 to attenuate particulate matter-induced MMP-1 and inflammation in human keratinocytes. [PDF]
Yun J, Kim JE.
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MAP kinase kinase kinases and innate immunity
Trends in Immunology, 2006Toll-like receptors, which respond to invariant microbial molecules, and receptors for the proinflammatory cytokines tumour necrosis factor and interleukin-1 are crucial for initiation and regulation of innate immune responses. These receptors activate each of the major mitogen-activated protein (MAP) kinase subtypes, extracellular signal-regulated ...
Sören Beinke+2 more
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Biochemical and Biophysical Research Communications, 1998
In plants, a number of MAP kinase (MAPK), MAPK kinase (MAPKK), and MAPKK kinase (MAPKKK) homologues have been reported. However, there have been no reports of protein-protein interactions between these kinases or molecular analysis of MAPK cascades in higher plants.
Kenji Irie+6 more
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In plants, a number of MAP kinase (MAPK), MAPK kinase (MAPKK), and MAPKK kinase (MAPKKK) homologues have been reported. However, there have been no reports of protein-protein interactions between these kinases or molecular analysis of MAPK cascades in higher plants.
Kenji Irie+6 more
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Plant MAP kinase kinase kinases structure, classification and evolution
Gene, 1999The increasing number of reports describing plant MAP kinase signalling components reflects the cardinal role that MAP kinase pathways are likely to play during plant growth and development. Relationship and structural analyses of plant MAP kinase kinase kinase related cDNAs and genes established, on one hand, the PMEKKs, which may be distinguished ...
Stefan Jouannic+5 more
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Raf-1 activates MAP kinase-kinase
Nature, 1992The normal cellular homologue of the acutely transforming oncogene v-raf is c-raf-1, which encodes a serine/threonine protein kinase that is activated by many extracellular stimuli. The physiological substrates of the protein c-Raf-1 are unknown.
Harald App+6 more
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The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)
Frontiers in Bioscience, 2008The human MAP kinase-interacting kinases (or MAP kinase signal-integrating kinases), Mnks, comprise a group of four proteins derived from two genes (Gene symbols: MKNK1 and MKNK2) by alternative splicing. Mnk1a/b differ at their C-termini, as do Mnk2a/2b: in each case, the a-form possesses a longer C-terminal region than the b-form, which lacks the MAP
Buxade, Maria+2 more
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Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor.
Science, 1998Anthrax lethal toxin, produced by the bacterium Bacillus anthracis, is the major cause of death in animals infected with anthrax. One component of this toxin, lethal factor (LF), is suspected to be a metalloprotease, but no physiological substrates have ...
N. Duesbery+10 more
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