Results 101 to 110 of about 1,192,359 (196)
Cell Communication and Signaling, 2012 Background Increased expression of the pro-fibrotic protein connective tissue growth factor (CTGF) has been detected in injured kidneys and elevated urinary levels of CTGF are discussed as prognostic marker of chronic kidney disease.
Zuehlke Jonathan +3 more
doaj +1 more source
Sustained oscillations in the MAP kinase cascade [PDF]
arXiv, 2015 The MAP kinase cascade is a network of enzymatic reactions arranged in layers. In each layer occurs a multiple futile cycle of phosphorylations. The fully phosphorylated substrate then serves as an enzyme for the layer below. This papers focusses on the existence of parameters for which Hopf bifurcations occur and generate periodic orbits.
arxiv
Overview of Current Type I/II Kinase Inhibitors [PDF]
arXiv, 2018 Research on kinase-targeting drugs has made great strides over the last 30 years and is attracting greater attention for the treatment of yet more kinase-related diseases. Currently, 42 kinase drugs have been approved by the FDA, most of which (39) are Type I/II inhibitors.
arxiv
Molecular components of PAMP-triggered oxidative burst in plant immunity [PDF]
, 2009 Reactive oxygen species (ROS) are important molecules that are rapidly generated in response to abiotic and biotic stimuli and which regulate diverse physiological processes such as stomatal aperture and cell death.
Mersmann, Sophia
core
Optimal length and signal amplification in weakly activated signal transduction cascades
, 2003 Weakly activated signaling cascades can be modeled as linear systems. The input-to-output transfer function and the internal gain of a linear system, provide natural measures for the propagation of the input signal down the cascade and for the ...
Chaves, Madalena +2 more
core +2 more sources
Rule-based Modeling and Simulation of Biochemical Systems with Molecular Finite Automata [PDF]
arXiv, 2010 We propose a theoretical formalism, molecular finite automata (MFA), to describe individual proteins as rule-based computing machines. The MFA formalism provides a framework for modeling individual protein behaviors and systems-level dynamics via construction of programmable and executable machines.
arxiv
HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients
Cell Reports, 2017 Summary: Inhibition of the ATPase cycle of the HSP90 chaperone promotes ubiquitylation and proteasomal degradation of its client proteins, which include many oncogenic protein kinases.
Zhaobo Li +4 more
doaj
ATP concentration regulates enzyme kinetics [PDF]
arXiv, 2014 Adenosine 5'-triphosphate (ATP) is the nearly ubiquitous "energy currency" of living organisms, and thus is a crucial participant in the majority of enzymatic reactions. The standard models in enzyme kinetics generally ignore the temporal dynamics of ATP because it is assumed to be present in large excess.
arxiv
Multiple Xanthomonas euvesicatoria Type III Effectors Inhibit flg22-Triggered Immunity
Molecular Plant-Microbe Interactions, 2016 Xanthomonas euvesicatoria is the causal agent of bacterial spot disease in pepper and tomato. X. euvesicatoria bacteria interfere with plant cellular processes by injecting effector proteins into host cells through the type III secretion (T3S) system ...
Georgy Popov +3 more
doaj +1 more source
Hypergraphic Oriented Matroid Relational Dependency Flow Models of Chemical Reaction Networks [PDF]
arXiv, 2009 In this paper we derive and present an application of hypergraphic oriented matroids for the purpose of enumerating the variable interdependencies that define the chemical complexes associated with the kinetics of non-linear dynamical system representations of chemical kinetic reaction flow networks. The derivation of a hypergraphic oriented matroid is
arxiv