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Impact of PAMAM delivery systems on signal transduction pathways in vivo: Modulation of ERK1/2 and p38 MAP kinase signaling in the normal and diabetic kidney

International Journal of Pharmaceutics, 2016
The in vivo impact of two generation 6 cationic polyamidoamine (PAMAM) dendrimers on cellular signaling via extracellular-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (p38 MAPK), as well as their relationship to epidermal growth factor receptor (EGFR), were studied in the normal and/or diabetic rat kidney. A single 10mg/kg/i.p
Ibrahim F. Benter +5 more
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Methods to Study MAP Kinase Signalling in the Central Nervous System

, 2010
The mitogen-activated protein kinase (MAPK) family of intracellular signal transducers includes ERK1/2, ERK5, JNK/SAPK, and p38 and has been shown to control survival, proliferation and differentiation of cells composing the central and peripheral nervous system.
Maria Sibilia, Bettina Wagner
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THE ROLE OF THEhsp90-BASED CHAPERONE SYSTEM IN SIGNAL TRANSDUCTION BY NUCLEAR RECEPTORS AND RECEPTORS SIGNALING VIA MAP KINASE

Annual Review of Pharmacology and Toxicology, 1997
▪ Abstract The multicomponent heat-shock protein (hsp) 90–based chaperone system is an ubiquitous protein-folding system in the cytoplasm of eukaryotes. Several signal transduction systems utilize an interaction with hsp90 as an essential component of the signaling pathway.
William B. Pratt
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The MAP Kinase Signaling Cascades: A System of Hundreds of Components Regulates a Diverse Array of Physiological Functions

, 2010
Sequential activation of kinases within the mitogen-activated protein (MAP) kinase (MAPK) cascades is a common, and evolutionary-conserved mechanism of signal transduction. Four MAPK cascades have been identified in the last 20 years and those are usually named according to the MAPK components that are the central building blocks of each of the ...
Rony Seger, Yonat Keshet
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The endosomal–vacuolar transport system acts as a docking platform for the Pmk1 MAP kinase signaling pathway in Magnaporthe oryzae

New Phytologist
Summary In Magnaporthe oryzae, the Pmk1 MAP kinase signaling pathway regulates appressorium formation, plant penetration, effector secretion, and invasive growth. While the Mst11‐Mst7‐Pmk1 cascade was characterized two decades ago, knowledge of its signaling in the intracellular network remains limited.
Qing Wang +10 more
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Multiple Redox Regulation of the Cellular Signaling System Linked to AP‐1 and NFκB: Effects of N‐Acetylcysteine and H₂O₂ on the Receptor Tyrosine Kinases, the MAP Kinase Cascade, and IκB Kinases