Results 61 to 70 of about 328,504 (254)

The action of obestatin in skeletal muscle repair: stem cell expansion, muscle growth, and microenvironment remodeling [PDF]

, 2015
The development of therapeutic strategies for skeletal muscle diseases, such as physical injuries and myopathies, depends on the knowledge of regulatory signals that control the myogenic process. The obestatin/GPR39 system operates as an autocrine signal
ADAMO, Sergio, C. S. Mosteiro, D. l. Beiroa, F. F. Casanueva, I. Santos Zas, J. E. Viñuela, J. González Sánchez, J. M. Renaud, J. P. Camiña, J. Señarís, MORESI, Viviana, R. Gallego, R. Nogueiras, T. García Caballero, U. Gurriarán Rodríguez, W. Lin, Y. Pazos   +16 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages. [PDF]

PLoS Pathogens, 2011
Parasitic worms alter their host's immune system to diminish the inflammatory responses directed against them, using very efficient immunomodulating molecules.
Christian Klotz, Thomas Ziegler, Ana Sofia Figueiredo, Sebastian Rausch, Matthew R Hepworth, Nadja Obsivac, Christine Sers, Roland Lang, Peter Hammerstein, Richard Lucius, Susanne Hartmann   +10 more
doaj   +1 more source

Regulation of anti-inflammatory gene expression in vascular endothelial cells by EPAC1 [PDF]

, 2015
Suppressor of cytokine signalling 3 (SOCS3) is a potent inhibitor of pro-inflammatory pathways involved in atherogenesis and the development of neo-intimal hyperplasia (NIH), which contributes to the in-stent re-stenosis responsible for the failure of ...
Palmer, Timothy P., Yarwood, Stephen J.
core   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Anti-cancer therapeutic strategies based on HGF/MET, EpCAM, and tumor-stromal cross talk

Cancer Cell International, 2022
As an intelligent disease, tumors apply several pathways to evade the immune system. It can use alternative routes to bypass intracellular signaling pathways, such as nuclear factor-κB (NF-κB), Wnt, and mitogen-activated protein (MAP)/phosphoinositide 3 ...
Khadijeh Barzaman, Rana Vafaei, Mitra Samadi, Mohammad Hossein Kazemi, Aysooda Hosseinzadeh, Parnaz Merikhian, Shima Moradi-Kalbolandi, Mohammad Reza Eisavand, Houra Dinvari, Leila Farahmand   +9 more
doaj   +1 more source

Effect of IL-33 on pyroptosis of macrophages in mice with sepsis via NF-κB/p38 MAPK signaling pathway

Acta Cirúrgica Brasileira, 2021
Purpose To demonstrate the effect of IL-33 on the macrophage pyroptosis in mice with sepsis through the NF-kB/p38 MAPK signal pathway. Methods In total, 24 C57BL/6 mice were divided into the sham operation group (sham) and the cecal ligation and ...
Jingnuan Ke, Guolong Cai
doaj   +1 more source

Strain-dependent host transcriptional responses to toxoplasma infection are largely conserved in mammalian and avian hosts [PDF]

, 2011
Toxoplasma gondii has a remarkable ability to infect an enormous variety of mammalian and avian species. Given this, it is surprising that three strains (Types I/II/III) account for the majority of isolates from Europe/North America.
A Khaminets, A Khan, A Khan, A Subramanian, AI Saeed, AM Pollard, B Gajria, CA Dobbin, CN Kaneto, D Ajzenberg, DS Roos, DV Pechkovsky, EE Rosowski, G Dennis Jr, GS Yap, IJ Blader, J Laliberté, JC Boothroyd, John C. Boothroyd, Jon P. Boyle, JP Boyle, JP Dubey, JP Dubey, JP Dubey, JP Dubey, JP Saeij, JPJ Saeij, JPJ Saeij, JS Stumhofer, K Friedrich, KD Jensen, KW Broman, L Peixoto, LG Rahme, M Kieslinger, M Yamamoto, M Yamamoto, MA Miller, MB Angeloni, ME Grigg, Mohamed-Ali Hakimi, P Jourdan, P Kaiser, P Kaiser, PM Robben, R Hernandez, R Irizarry, RS Lewis, RT Gazzinelli, S Hemmers, S Mitra, S Taylor, SJ Fentress, T Ikeda, T Steinfeldt, VG Tusher, VK Mootha, W Huang da, X Xie, YC Ong, Yi-Ching Ong   +60 more
core   +5 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

ERK5 and cell proliferation: nuclear localization is what matters

Frontiers in Cell and Developmental Biology, 2016
ERK5, the last MAP kinase family member discovered, is activated by the upstream kinase MEK5 in response to growth factors and stress stimulation. MEK5-ERK5 pathway has been associated to different cellular processes, playing a crucial role in cell ...
Nestor Gomez, Tatiana Erazo, Jose M Lizcano   +2 more
doaj   +1 more source