Results 71 to 80 of about 1,192,359 (196)
The microbial zoo in the C. elegans intestine: Bacteria, fungi and viruses [PDF]
, 2016 Press freedom has become one of the major challenges facing Journalism practice in the world. This paper explores the factors hindering press freedom in Nigeria using some relevant examples.
Jiang, Hongbing, Wang, David
core +3 more sources
Why epithelial cells collectively move against a traveling signal wave [PDF]
arXiv, 2020 The response of cell populations to external stimuli plays a central role in biological mechanical processes such as epithelial wound healing and developmental morphogenesis. Wave-like propagation of a signal of ERK MAP kinase has been shown to direct collective migration in one direction; however, the mechanism based on continuum mechanics under a ...
arxiv
BMC Immunology, 2007 Background Mycobacterium tuberculosis (Mtb) causes death of 2–3 million people every year. The persistence of the pathogenic mycobacteria inside the macrophage occurs through modulation of host cell signaling which allows them, unlike the other non ...
Mir Fayaz +5 more
doaj +1 more source
BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival [PDF]
, 2015 B cell activating factor (BAFF) stimulation of the BAFF receptor (BAFF-R) is essential for the homeostatic survival of mature B cells. Earlier in vitro experiments with inhibitors that block MEK 1 and 2 suggested that activation of ERK 1 and 2 MAP ...
Jacque, E +3 more
core +1 more source
Animal Models for Coffin-Lowry Syndrome: RSK2 and Nervous System Dysfunction
Frontiers in Behavioral Neuroscience, 2018 Loss of function mutations in the rsk2 gene cause Coffin-Lowry syndrome (CLS), which is associated with multiple symptoms including severe mental disabilities.
Matthias Fischer, Thomas Raabe
doaj +1 more source
Genetic and proteomic evidence for roles of Drosophila SUMO in cell cycle control, Ras signaling, and early pattern formation. [PDF]
PLoS ONE, 2009 SUMO is a protein modifier that is vital for multicellular development. Here we present the first system-wide analysis, combining multiple approaches, to correlate the sumoylated proteome (SUMO-ome) in a multicellular organism with the developmental ...
Minghua Nie +3 more
doaj +1 more source
Structural insights into characterizing binding sites in EGFR kinase mutants [PDF]
Journal of Chemical Information and Modeling, 2018, 2018 Over the last two decades epidermal growth factor receptor (EGFR) kinase has become an important target to treat non-small cell lung cancer (NSCLC). Currently, three generations of EGFR kinase-targeted small molecule drugs have been FDA approved. They nominally produce a response at the start of treatment and lead to a substantial survival benefit for ...
arxiv +1 more source
Genetic disruption of the core circadian clock impairs hippocampus-dependent memory [PDF]
, 2014 Perturbing the circadian system by electrolytically lesioning the suprachiasmatic nucleus (SCN) or varying the environmental light:dark schedule impairs memory, suggesting that memory depends on the circadian system.
Chen, Xuanmao +4 more
core +2 more sources
G3: Genes, Genomes, Genetics, 2016 Inositol 1,4,5-trisphosphate (IP3) regulates a host of biological processes from egg activation to cell death. When IP3-specific receptors (IP3Rs) bind to IP3, they release calcium from the ER into the cytoplasm, triggering a variety of cell type- and ...
Derek M. Dean +5 more
doaj +1 more source
Functions of Bifans in Context of Multiple Regulatory Motifs in Signaling Networks [PDF]
, 2007 Representation of intracellular signaling networks as directed graphs allows for the identification of regulatory motifs. Regulatory motifs are groups of nodes with the same connectivity structure, capable of processing information. The bifan motif, made of two source nodes directly cross-regulating two target nodes, is an over-represented motif in a ...
arxiv +1 more source