Positional information readout in $Ca^{2+}$ signaling [PDF]
Phys. Rev. Lett. 123, 058102 (2019), 2017 Living cells respond to spatial signals. Signal transmission to the cell interior often involves the release of second messengers like $Ca^{2+}$ . They will eventually trigger a physiological response by activating kinases that in turn activate target proteins through phosphorylation. Here, we investigate theoretically how positional information can be
arxiv +1 more source
Estimation of kinetic rates of MAP kinase activation from experimental data [PDF]
, 2009 Mathematical model is an important tool in systems biology to study the dynamics of biological systems inside the cell. One of the significant challenges in systems biology is the lack of kinetic rates that should be measured in experiments or estimated ...
Tian, T.
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ERK-1 MAP kinase prevents TNF-induced apoptosis through bad phosphorylation and inhibition of bax translocation in HeLa cells [PDF]
, 2009 Extracellular signal-regulated kinase (ERK) 1/2 signaling is involved in tumor cell survival through the regulation of Bcl-2 family members. To explore this further and to demonstrate the central role of the mitochondria in the ERK1/2 pathway we used the
Aventaggiato, Michele +10 more
core +1 more source
Characterizing Autism Spectrum Disorders by Key Biochemical Pathways
Frontiers in Neuroscience, 2015 The genetic and phenotypic heterogeneity of autism spectrum disorders (ASD) presents a substantial challenge for diagnosis, classification, research, and treatment.
Megha eSubramanian +4 more
doaj +1 more source
Current Plant Biology, 2016 In plants, the sucrose non-fermenting (SNF1)-related protein kinase 1 (SnRK1) represents a central integrator of low energy signaling and acclimation towards many environmental stress responses.
Madlen Nietzsche +3 more
doaj +1 more source
Surveillance-activated defenses block the ROS-induced mitochondrial unfolded protein response. [PDF]
PLoS Genetics, 2013 Disturbance of cellular functions results in the activation of stress-signaling pathways that aim at restoring homeostasis. We performed a genome-wide screen to identify components of the signal transduction of the mitochondrial unfolded protein response
Eva D Runkel +3 more
doaj +1 more source
praja2 regulates KSR1 stability and mitogenic signaling [PDF]
, 2016 The kinase suppressor of Ras 1 (KSR1) has a fundamental role in mitogenic signaling by scaffolding components of the Ras/MAP kinase pathway. In response to Ras activation, KSR1 assembles a tripartite kinase complex that optimally transfers signals ...
Bachmann, V +13 more
core +1 more source
Analysis of FGF-dependent and FGF-independent pathways in otic placode induction. [PDF]
PLoS ONE, 2013 The inner ear develops from a patch of thickened cranial ectoderm adjacent to the hindbrain called the otic placode. Studies in a number of vertebrate species suggest that the initial steps in induction of the otic placode are regulated by members of the
Lu Yang +6 more
doaj +1 more source
Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation. [PDF]
, 2015 Inflammatory critical illness is a syndrome that is characterized by acute inflammation and organ injury, and it is triggered by infections and noninfectious tissue injury, both of which activate innate immune receptors and pathways.
Farrar, Katherine +9 more
core +1 more source
Effects of keratin filaments on ERK signaling during Fas-induced death of cervical cancer (HeLa) cells [PDF]
, 2014 Survival of cancer cells is influenced by a variety of factors, including physical elements such as keratin filaments. We know HeLa cells containing or lacking keratin 8/18 intermediate filaments (K+ and K- cells, respectively) are more sensitive to the ...
Berger, Amanda
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