Results 41 to 50 of about 1,028 (92)

基于网络药理学探索梅花草提取物抑制脑胶质瘤的作用机制

Zhongguo shiyan zhenduanxue
目的 运用网络药理学技术结合细胞及动物实验探讨梅花草提取物抑制脑胶质瘤恶性增殖的作用机制。方法 通过中药系统药理学分析平台(TCMSP)数据库筛选梅花草的有效化合物，使用OMIM、Genecards、Pubchem等数据库预测梅花草有效化合物对脑胶质瘤的潜在作用靶点，应用Cytoscape 3.9.1和STRING 11.5数据库构建化合物-靶点网络、蛋白质互作(PPI),筛选出核心基因，运用DAVID 6.8数据库对靶点进行基因本体(GO)的富集分析和京都基因与基因组百科全书(KEGG)的通路富集分析，
王睿君, 马宇衡, 王儒帅, 何占彪   +3 more
doaj  

TREM-1在细菌性化脓性角膜炎中的作用及其分子机制

Zhongshan Daxue xuebao. Yixue kexue ban, 2012
【目的】 探讨髓样细胞诱发受体1(TREM-1)在铜绿假单胞菌(PA)感染角膜炎中的作用及其分子机制。【方法】为了揭示TREM-1在细菌性角膜炎中的作用,我们建立了PA角膜炎小鼠模型和PA感染的腹腔巨噬细胞模型,real-time PCR和免疫荧光法检测感染前后TREM-1的表达水平;用丝裂原活化蛋白激酶(MAPKs)的抑制剂或磷脂酰肌醇3-激酶(PI3K)抑制剂预处理巨噬细胞,再用脂多糖(LPS)和TREM-1活化抗体刺激,real-time PCR检测IL-1β、MIP-2、TNF-α和IL ...
doaj  

[Sulforaphane reduces reactive astrocyte-mediated neuron apoptosis <i>in vitro</i> by inhibiting the MAPK/NF-κB signaling pathway in Aβ42 oligomer-activated astrocytes]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Zhang S, Huang T, Yang C, Chen J, Lü T, Zhang J.   +5 more
europepmc   +1 more source

[Research progress on lactylation modification in pathogenesis of osteoarthritis]. [PDF]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Wu Y, Sun K, Ding Y, Li M, Liu Y, Wu L, Peng L, Shen B.   +7 more
europepmc   +1 more source

[Mechanism of Trifolin in Attenuating Hypertension-Induced Renal Cell Apoptosis via Modulation of the MAPK Signaling Pathway]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
Wu M, Guo Z, Xie Y, Liu H, Chen H, Lin X, Chen R, Shen A, Peng J.   +8 more
europepmc   +1 more source

[<i>Shenqi Xiezhuo</i> Decoction alleviates renal fibrosis in rats by ameliorating oxidative stress and inflammation through the Rap1/MAPK/FoxO3a signaling pathway]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Lu X, Liu Z, Liu Y, Pang T, Bian R, Guo L, He X.   +6 more
europepmc   +1 more source

[Nuclear Factor I-X Regulates Molecular Pathways Related to Craniofacial Development Through Phase Separation]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
Wang J, Fan Y, Xu R, Jing J, Zhou X.
europepmc   +1 more source

[Molecular Mechanism of Neutrophils Driving the Progression of Lung Adenocarcinoma]. [PDF]

Zhongguo Fei Ai Za Zhi
Li X, Li L.
europepmc   +1 more source

[Niranthin ameliorates Crohn's disease-like enteritis in mice by inhibiting intestinal epithelial cell apoptosis and protecting intestinal barrier <i>via</i> modulating p38/JNK signaling]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Tao L, Chen Y, Huang L, Zheng W, Song X, Xiang P, Hu J.   +6 more
europepmc   +1 more source

[Interferon-λ1 improves glucocorticoid resistance caused by respiratory syncytial virus by regulating the p38 mitogen-activated protein kinase signaling pathway]. [PDF]

Zhongguo Dang Dai Er Ke Za Zhi
Peng L, Liu Y, Li FC, Ding XF, Lin XJ, Yang TH, Zhong LL.   +6 more
europepmc   +1 more source