Results 41 to 50 of about 1,127 (92)

基于网络药理学探索梅花草提取物抑制脑胶质瘤的作用机制

Zhongguo shiyan zhenduanxue
目的 运用网络药理学技术结合细胞及动物实验探讨梅花草提取物抑制脑胶质瘤恶性增殖的作用机制。方法 通过中药系统药理学分析平台(TCMSP)数据库筛选梅花草的有效化合物，使用OMIM、Genecards、Pubchem等数据库预测梅花草有效化合物对脑胶质瘤的潜在作用靶点，应用Cytoscape 3.9.1和STRING 11.5数据库构建化合物-靶点网络、蛋白质互作(PPI),筛选出核心基因，运用DAVID 6.8数据库对靶点进行基因本体(GO)的富集分析和京都基因与基因组百科全书(KEGG)的通路富集分析，
王睿君, 马宇衡, 王儒帅, 何占彪   +3 more
doaj  

TREM-1在细菌性化脓性角膜炎中的作用及其分子机制

Zhongshan Daxue xuebao. Yixue kexue ban, 2012
【目的】 探讨髓样细胞诱发受体1(TREM-1)在铜绿假单胞菌(PA)感染角膜炎中的作用及其分子机制。【方法】为了揭示TREM-1在细菌性角膜炎中的作用,我们建立了PA角膜炎小鼠模型和PA感染的腹腔巨噬细胞模型,real-time PCR和免疫荧光法检测感染前后TREM-1的表达水平;用丝裂原活化蛋白激酶(MAPKs)的抑制剂或磷脂酰肌醇3-激酶(PI3K)抑制剂预处理巨噬细胞,再用脂多糖(LPS)和TREM-1活化抗体刺激,real-time PCR检测IL-1β、MIP-2、TNF-α和IL ...
doaj  

[Research progress on the quercetin target role and signaling pathway in anti-liver fibrosis]. [PDF]

Zhonghua Gan Zang Bing Za Zhi
Zhao RQ, Liu HY, Yan JM, Hao Y, Ding YX, Zhang F, Zhou RM, Zhao R, Bai F, Bai WF.   +9 more
europepmc   +1 more source

[Application of Kartogenin in cartilage tissue engineering]. [PDF]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Jiang J, Zhang S, Lu W.
europepmc   +1 more source

[Advances on efficacy and mechanisms of acid fibroblast growth factor for promoting injured tissue repair]. [PDF]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Zhu F, Jiang Z, Qian X, Xu Y, Cheng H, Zhang J.   +5 more
europepmc   +1 more source

[<i>Yiqi Jiedu</i> Formula inhibits proliferation, invasion and migration of nasopharyngeal carcinoma cells by inhibiting the AKT1/GLUT1 signaling pathway]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Xu H, He L, Xiong Y, Zou F, Lin T, Jiang Z, Tang L, He Y, Zhou F.   +8 more
europepmc   +1 more source

[Sulforaphane reduces reactive astrocyte-mediated neuron apoptosis <i>in vitro</i> by inhibiting the MAPK/NF-κB signaling pathway in Aβ42 oligomer-activated astrocytes]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Zhang S, Huang T, Yang C, Chen J, Lü T, Zhang J.   +5 more
europepmc   +1 more source

[Liver-bone axis: novel mechanisms and strategies for MAFLD regulation]. [PDF]

Zhonghua Gan Zang Bing Za Zhi
Wang YW, Yan XZ, You H, Yang AT.
europepmc   +1 more source

[The role and mechanism of chemokine network in promoting osteoarthritis progression by regulating synovial macrophage heterogeneity]. [PDF]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Lin Y, Wu L, Chen Q, Shen B.
europepmc   +1 more source

[Research progress on lactylation modification in pathogenesis of osteoarthritis]. [PDF]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Wu Y, Sun K, Ding Y, Li M, Liu Y, Wu L, Peng L, Shen B.   +7 more
europepmc   +1 more source