Results 181 to 190 of about 381,210 (291)

Tempol Attenuates Methotrexate-Induced Osteotoxicity via Antioxidant Mechanisms: Impairment of Protection by GPX4 Inhibition Through ML210. [PDF]

Curr Issues Mol Biol
Arpağ OF, Selimli F, Haskan AC, Altun MS, Mete S, Kaplan HM.   +5 more
europepmc   +1 more source

A Role for MAPK in Feedback Inhibition of Tcrb Recombination [PDF]

, 2006
Annette M. Jackson, Michael S. Krangel
openalex   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

ROS-responsive Ganoderma lucidum polysaccharide nanocomposite targeting prosenescent oxidative stress niche for structural and functional diabetic tendon regeneration. [PDF]

J Nanobiotechnology
Gao Y, Wang H, Sheng R, Shi L, Zhang Y, Song Z, Rong Y, Han B, Cao M, Lu P, Dai G, Li Y, Zhang W, Rui Y.   +13 more
europepmc   +1 more source

Verification of the role of Mycobacterium leprae in the activation of MAPKs in human and murine peripheral nerves

, 2023
Mariane Bertolucci [UNESP] Casalenovo
openalex   +1 more source

The Role of Phospholipase D and MAPK Signaling Cascades in the Adaption of Lichen Microalgae to Desiccation: Changes in Membrane Lipids and Phosphoproteome [PDF]

, 2016
Francisco Gasulla, Eva Barreno, María L. Parages, Joaquín Cámara, Carlos Jiménez, Peter Dörmann, Dorothea Bartels   +6 more
openalex   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1‐Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation

Advanced Science, EarlyView.
Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li, Chenli Si, Xue Wang, Xiaojin Wu, Ying Shang, Shengfang Ge, Yong Wang, Yong Zuo, Zhen Zhang   +8 more
wiley   +1 more source

Natural products targeting the MAPK signaling pathway: potential options for ulcerative colitis treatment. [PDF]

Front Pharmacol
Li C, Li Z, Zheng Y.
europepmc   +1 more source

Retracted: Protective effects of microRNA‐330 on amyloid β‐protein production, oxidative stress, and mitochondrial dysfunction in Alzheimer's disease by targeting VAV1 via the MAPK signaling pathway [PDF]

, 2018
Ying Zhou, Zhoufan Wang, Wěi Li, Hui Hong, Juan Chen, Yi Tian, Zhaoyun Liu   +6 more
openalex   +1 more source