Results 231 to 239 of about 514,036 (239)
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MAPKs: new targets for neurodegeneration
Expert Opinion on Therapeutic Targets, 2003Neurodegenerative diseases remain a huge unmet pharmaceutical need. For some diseases such as Parkinson's disease, there are currently only palliative therapies, and for others such as Alzheimer's disease there are no proven therapies on the market that have any significant impact on disease progression.
Neil Wilkie, Sarah J. Harper
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Inhibition of MAPK Pathway by a Synthetic Peptide Corresponding to the Activation Segment of MAPK
Biochemical and Biophysical Research Communications, 1998Mitogen-activated protein kinase (MAPK) is activated by phosphorylation within its activation segment. Upon phosphorylation, the activation segment refolds to provide the active conformation of the enzyme. We reported previously that a phosphorylation-sensitive secondary structure could be formed in a 26-amino-acid long synthetic peptide corresponding ...
Kumiko Konaka +4 more
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2016
Dysregulation of the mitogen-activated protein kinase (MAPK) pathway has been associated with various neoplasms including melanomas. Common alterations in the MAPK pathway in melanomas include mutations in BRAF, EGFR, KIT, RAS, MEK, and ERK. The increased understanding of the biology and genetics of melanoma has generated interest in targeting the MAPK
Phyu P. Aung +2 more
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Dysregulation of the mitogen-activated protein kinase (MAPK) pathway has been associated with various neoplasms including melanomas. Common alterations in the MAPK pathway in melanomas include mutations in BRAF, EGFR, KIT, RAS, MEK, and ERK. The increased understanding of the biology and genetics of melanoma has generated interest in targeting the MAPK
Phyu P. Aung +2 more
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Biochemical Journal, 2012
Plants contain hundreds of protein kinases that are believed to provide cellular signal transduction services, but the identities of the proteins they are targeting are largely unknown. Using an Arabidopsis MAPK (mitogen-activated protein kinase) (MPK6) as a model, Sörensson et al.
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Plants contain hundreds of protein kinases that are believed to provide cellular signal transduction services, but the identities of the proteins they are targeting are largely unknown. Using an Arabidopsis MAPK (mitogen-activated protein kinase) (MPK6) as a model, Sörensson et al.
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Science, 2000
Exactly how signaling proteins know where they need to be in the cell is one of the intriguing mysteries of signal transduction biology. In a Perspective, PouyssA©gur reviews new results that identify b-arrestin 2 as a scaffolding protein that holds together the different components of a MAPK signaling pathway that activates the transcription ...
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Exactly how signaling proteins know where they need to be in the cell is one of the intriguing mysteries of signal transduction biology. In a Perspective, PouyssA©gur reviews new results that identify b-arrestin 2 as a scaffolding protein that holds together the different components of a MAPK signaling pathway that activates the transcription ...
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Mechanisms of MAPK kinase-independent p38-MAPK activation
Journal of Molecular and Cellular Cardiology, 2008Michael S. Marber +2 more
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