Results 231 to 240 of about 381,210 (291)

Vitamin D3 mediates amelioration of ulcerative colitis via the TRPV1-MAPK signaling pathway. [PDF]

Front Immunol
Zhao K, Li J, Asai Y, Zhang L, Hu Z, Gao H.   +5 more
europepmc   +1 more source

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

Mechanism Study of Yi-Qi-Dao-Zhi Formula in Improving Postoperative Ileus by Targeting the TLR4/NF-κB/MAPK Signaling Pathways. [PDF]

J Inflamm Res
Yu J, Zhao X, Zhang L, Chen Y, Zhang T, Wang Y, Yi C, Pan H, Wang H, Ge M, Jiang Z, Wang G.   +11 more
europepmc   +1 more source

Summary table of sequence identity and similarity between Fus3 (PDB ID: 2b9f), TbERK8, HsERK8, and the MAPK template (PDB ID: 3oz6) sequences.

Matthew Merski (1294668), Zachary B. Mackey (138942)   +1 more
openalex   +1 more source

Bilirubin as a Modulator of WNK1 Protein Signaling: Implications for Neuroinflammatory Diseases

Advanced Science, EarlyView.
ABSTRACT Previously regarded merely as a potentially harmful waste product of heme catabolism, bilirubin has now emerged as a pleiotropic molecule with potent antioxidant, anti‐inflammatory, and hormone‐like properties. Recent findings have revealed protective effects against cardiovascular, metabolic, autoimmune, and neoplastic diseases, as well as ...
Sri Jayanti, Libor Vítek, Silvia Gazzin, Claudio Tiribelli   +3 more
wiley   +1 more source

Qing-Xin-Jie-Yu granule prevents myocardial infarction-induced apoptosis via inhibition of p38 MAPK pathway. [PDF]

Front Cardiovasc Med
Qi J, Cai Q, Han Y, Gao X, Yang M, Wei C, Wang K, Lyu Z, Lin Y, Zhang L, Gao Z, Chu J.   +11 more
europepmc   +1 more source

Table 2_Phytochemical-rich Eucommia ulmoides leaf extract extends healthspan in Caenorhabditis elegans via the pmk-1/p38 MAPK pathway and mitochondrial homeostasis.xlsx

Jiaxu Zhang (1942288), Quhuan Ma (22499921), Jiaojiao Li (817846), Xingwen Xie (15364183), Xiaofeng Shi (140419)   +4 more
openalex   +1 more source

Self‐Adaptive Allantoin@ZIF8 Nanocomposite Hydrogel with Resveratrol Synergy for MRSA‐Infected Wound Regeneration

Advanced Science, EarlyView.
Based on allantoin‐loaded ZIF8 nanoparticles (Alla@ZIF8) and methacrylated quaternary ammonium carboxymethyl chitosan/resveratrol composite hydrogels (RMQCC), an adaptive multifunctional hydrogel system (Alla@ZIF8‐Gel) was constructed and confirmed to induce the healing of MRSA‐infected wounds via suppressing bacterial proliferation, alleviating ...
Yongjie Zhu, Dun Liu, Mengran Zhao, Xinyi Jian, Enuo Peng, Xingping Zhao, Zezhang Zhu, Bolin Tang, Benlong Shi   +8 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source