Results 11 to 20 of about 490,180 (313)
International Journal of Molecular Sciences, 2022 Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is limited due to the metastasis of cells to distant locations of the body through the blood and lymphatic drainage. Most of the anticancer therapeutic options focus mainly on the inhibition of tumor cell growth or the induction of cell death, and do not consider ...
Mateusz Kciuk +4 more
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Organophosphorus Compounds and MAPK Signaling Pathways [PDF]
International Journal of Molecular Sciences, 2020 The molecular signaling pathways that lead to cell survival/death after exposure to organophosphate compounds (OPCs) are not yet fully understood. Mitogen-activated protein kinases (MAPKs) including the extracellular signal-regulated protein kinase (ERK), the c-Jun NH2-terminal kinase (JNK), and the p38-MAPK play the leading roles in the transmission ...
Tahereh Farkhondeh +5 more
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MAPK pathways in radiation responses [PDF]
Oncogene, 2003 Within the last 15 years, multiple new signal transduction pathways within cells have been discovered. Many of these pathways belong to what is now termed 'the mitogen-activated protein kinase (MAPK) superfamily.' These pathways have been linked to the growth factor-mediated regulation of diverse cellular events such as proliferation, senescence ...
Paul, Dent +4 more
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The Ras/Raf/MAPK Pathway [PDF]
Journal of Thoracic Oncology, 2006 The Ras/Raf/MAPK pathway is probably the best characterized signal transduction pathway in cell biology. The function of this pathway is to transduce signals from the extracellular milieu to the cell nucleus where specific genes are activated for cell growth, division and differentiation.
Molina, Julian R., Adjei, Alex A.
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International Journal of Molecular Sciences, 2023 The name extracellular signal-regulated kinase (ERK) was first used for a cell cycle regulating Ser/Thr protein kinase cloned in mammalian cells [...]
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Understanding MAPK Signaling Pathways in Apoptosis [PDF]
International Journal of Molecular Sciences, 2020 MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological processes through multiple cellular mechanisms. In most of these processes, such as apoptosis, MAPKs have a dual role since they can act as activators or inhibitors, depending on the cell type and the stimulus.
Yue, Jicheng, López, José M.
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MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma [PDF]
Cancers, 2021 Hepatocellular carcinoma (HCC) is a major health concern worldwide, and its incidence is increasing steadily. Recently, the MAPK/ERK signaling pathway in HCC has gained renewed attention from basic and clinical researchers. The MAPK/ERK signaling pathway is activated in more than 50% of human HCC cases; however, activating mutations in RAS and RAF ...
Hyuk Moon, Simon Weonsang Ro
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Effectiveness of EGFR/HER2-targeted drugs is influenced by the downstream interaction shifts of PTPIP51 in HER2-amplified breast cancer cells [PDF]
, 2013 Breast cancer is the most common female cancerous disease and the second most cause of cancer death in women. About 20-30% of these tumors exhibit an amplification of the HER2/ErbB2 receptor, which is coupled to a more aggressive and invasive growth of ...
Brobeil, Alexander +4 more
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Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling. [PDF]
, 2020 BackgroundHeat shock protein 70 (Hsp70) has been shown to exert cardioprotection. Intracellular calcium ([Ca2+]i) overload induced by p38 mitogen-activated protein kinase (p38 MAPK) activation contributes to cardiac ischemia/reperfusion (I/R) injury ...
Chen, Qing-Cai +10 more
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Cancer Cell International, 2022 MAPK (mitogen-activated protein kinase) or ERK (extracellular-signal-regulated kinase) pathway is an important link in the transition from extracellular signals to intracellular responses. Because of genetic and epigenetic changes, signaling cascades are
Eunus S. Ali +10 more
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