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Science's STKE, 2005
This Teaching Resource provides lecture notes and slides for a class covering three kinase-mediated signaling pathways and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The focus is three major signaling cascades that are implicated in cell proliferation, survival, and stress response.
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This Teaching Resource provides lecture notes and slides for a class covering three kinase-mediated signaling pathways and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The focus is three major signaling cascades that are implicated in cell proliferation, survival, and stress response.
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2007
There are four members of the mammalian p38 mitogen-activated protein kinases (MAPKs) family (p38α, p38β, p38γ and p38δ) which are about 60% identical in their amino acid sequence but differ in their expression patterns, substrate specificities, and sensitivities to chemical inhibitors such as SB203580.
Francisco Iñesta-Vaquera +3 more
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There are four members of the mammalian p38 mitogen-activated protein kinases (MAPKs) family (p38α, p38β, p38γ and p38δ) which are about 60% identical in their amino acid sequence but differ in their expression patterns, substrate specificities, and sensitivities to chemical inhibitors such as SB203580.
Francisco Iñesta-Vaquera +3 more
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The Ras-MAPK Signal Transduction Pathway
Science Signaling, 2010Animated lessons illustrate a canonical signaling pathway activated by various hormones and growth factors.
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The MAPK signalling pathways and colorectal cancer
The Lancet Oncology, 2005There are three major subfamilies of mitogen-activated protein kinases (MAPK): the extracellular-signal-regulated kinases (ERK MAPK); the c-jun N-terminal kinase or stress-activated protein kinases (JNK or SAPK); and MAPK14. The ERK MAPK pathway is one of the most important for cell proliferation. The MAPK pathways are located downstream of many growth-
Jing Yuan, Fang, Bruce C, Richardson
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MAP kinase pathways activated by stress: The p38 MAPK pathway
Critical Care Medicine, 2000A stress-activated serine/threonine protein kinase, p38 mitogen-activated protein kinase (p38 MAPK), belongs to the MAP kinase superfamily. Diverse extracellular stimuli, including ultraviolet light, irradiation, heat shock, high osmotic stress, proinflammatory cytokines and certain mitogens, trigger a stress-regulated protein kinase cascade ...
T, Obata, G E, Brown, M B, Yaffe
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2016
Dysregulation of the mitogen-activated protein kinase (MAPK) pathway has been associated with various neoplasms including melanomas. Common alterations in the MAPK pathway in melanomas include mutations in BRAF, EGFR, KIT, RAS, MEK, and ERK. The increased understanding of the biology and genetics of melanoma has generated interest in targeting the MAPK
Leomar Y. Ballester +2 more
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Dysregulation of the mitogen-activated protein kinase (MAPK) pathway has been associated with various neoplasms including melanomas. Common alterations in the MAPK pathway in melanomas include mutations in BRAF, EGFR, KIT, RAS, MEK, and ERK. The increased understanding of the biology and genetics of melanoma has generated interest in targeting the MAPK
Leomar Y. Ballester +2 more
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Inhibitors of the MAPK pathway
2000The mitogen-activated protein kinase (MAPK) family of protein kinases is a series of three highly conserved protein kinases arrayed in a cascade. Members of this family are proline-directed serine/threonine kinases that are activated by dual-phosphorylation. MAPK belong to the rapidly growing family of mammalian protein kinases. Less than 200 mammalian
Brion W. Murray +2 more
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Impact of MAPK cascade pathway and P53 pathway upon liver transplant
Journal of Huazhong University of Science and Technology [Medical Sciences], 2005The change and the role of MAPK cascade pathway and P53 pathway after liver transplantation were explored. Thirty-four punctured donor liver specimens and 10 normal liver specimens were classified as group A (no rejection, n = 10), group B (mild/moderate acute rejection, n = 10), group C (serious acute rejection, n = 8), group D (chronic rejection ...
Nianqiao, Gong +4 more
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State machine modeling of MAPK signaling pathways
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2014Mitogen activated protein kinase (MAPK) signaling pathways are frequently deregulated in human cancers with potential involvement in most if not all cellular processes leading to tumorigenesis. Mathematical/computational models of MAPK signaling are indispensable to the study of pathway deregulation dynamics and their nonlinear effects on cell fate and
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Functional analysis of the MAPK pathways in fungi
Revista Iberoamericana de Micología, 2017The Mitogen-Activated Protein Kinase (MAPK) signaling pathways constitute one of the most important and evolutionarily conserved mechanisms for the perception of extracellular information in all the eukaryotic organisms. The MAPK pathways are involved in the transfer to the cell of the information perceived from extracellular stimuli, with the final ...
Domingo, Martínez-Soto +1 more
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