Results 41 to 50 of about 490,180 (313)
Modelling and analysis of biochemical signalling pathway cross-talk [PDF]
, 2010 Signalling pathways are abstractions that help life scientists structure the coordination of cellular activity. Cross-talk between pathways accounts for many of the complex behaviours exhibited by signalling pathways and is often critical in producing ...
Emanuela Merelli +3 more
core +5 more sources
Impact of MAPK Pathway Activation in BRAFV600 Melanoma on T Cell and Dendritic Cell Function
Frontiers in Immunology, 2013 Constitutive upregulation of the MAPK pathway by a BRAFV600 mutation occurs in about half of melanomas. This leads to increased oncogenic properties such as tumor cell invasion, metastatic potential, and resistance to apoptosis.
Patrick A. Ott, Nina Bhardwaj
doaj +1 more source
Non-genomic actions of estradiol and 4-OH-tamoxifen on murine breast cancer cells [PDF]
, 2015 Estrogens and tamoxifen do not only exert their effects at the genomic level, but also play a role at the cell membrane activating downstream signaling pathways. We recently characterized an estrogen receptor-positive epithelial murine breast cancer cell
Bal, Elisa Dora +3 more
core +2 more sources
Deciphering MAP kinase pathway in Cicer arietinum upon Helicoverpa armigera -infestation
Plant StressThe activation of Mitogen-Activated Protein Kinase (MAPK) pathway is recognized as a key regulator of the plant defense mechanisms in response to insect attacks.
Mansi Taneja +4 more
doaj +1 more source
Hydrazinocurcumin Induces Apoptosis of Hepatocellular Carcinoma Cells Through the p38 MAPK Pathway
Clinical and Translational Science, 2021 Hydrazinocurcumin (HZC), a synthetic derivative of curcumin (CUR), has been documented to show anticancer potential in impeding tumor growth in several cancers, including hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms remain
Hongtao He +8 more
doaj +1 more source
YAP in MAPK pathway targeted therapy resistance [PDF]
Cell Cycle, 2015 Within the past several years, there have been major advances in cancer treatment through the use of molecularly targeted therapy, though resistance to therapy remains a significant issue.
Keith T, Flaherty +2 more
openaire +2 more sources
Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors. [PDF]
PLoS ONE, 2017 Mitogen-activated protein kinase (MAPK) pathway dysregulation is implicated in >30% of all cancers, rationalizing the development of RAF, MEK and ERK inhibitors.
Mark Merchant +22 more
doaj +1 more source
Early and late effects of pharmacological ALK inhibition on the neuroblastoma transcriptome [PDF]
, 2017 Background: Neuroblastoma is an aggressive childhood malignancy of the sympathetic nervous system. Despite multi-modal therapy, survival of high-risk patients remains disappointingly low, underscoring the need for novel treatment strategies.
Cannoodt, Robrecht +6 more
core +3 more sources
Antioxidants, 2019 Oxidative stress plays a vital role in neurodegenerative diseases. Cornus officinalis (CC) has a wide range of pharmacological activities (e.g., antioxidant, neuroprotective, and anti-inflammatory).
Weishun Tian +7 more
doaj +1 more source
Open Life Sciences, 2022 The accumulation of β-amyloid (Aβ) in the brain plays an important role in the pathogenesis of Alzheimer’s disease (AD). The lack of estrogen is one of the risk factors for AD.
Liu Liangjing +6 more
doaj +1 more source