Results 141 to 150 of about 7,681 (165)

C-C chemokine receptor type 5 activation stimulates adipocyte differentiation through ERK-dependent pathway. [PDF]

Int J Med Sci
Chen LK, Chen CW, Wu SY, Liu SY, Wu LY, Chang CJ, Sy LB, Juan CC.   +7 more
europepmc   +1 more source

Role of HIV-1 in IL-8 response of human stellate cells to gram-positive microbial products. [PDF]

Sci Rep
Ali RO, Zhang L, Chamroonkul N, Tabrizian P, Schwartz M, Gunasekaran G, Schiano T, Fiel MI, Ward SC, Bansal MB.   +9 more
europepmc   +1 more source

The meningeal lymphatic vessel-peripheral immune axis: a novel therapeutic target in neurodegenerative diseases. [PDF]

J Neuroinflammation
He Z, Sun J.
europepmc   +1 more source

A Priori Design, Combinatorial Synthesis, and Assessment of an Antipackaging Peptide Against Human Immunodeficiency Virus 1: Functional Role of Unnatural Trp Mimetics and Serendipitous Discovery of a Protease Inhibitor. [PDF]

ChemMedChem
Immel JR, Chen PH, McDonald P, Roy A, Johnson D, Bloom S.   +5 more
europepmc   +1 more source

Maraviroc Prevents Optic Nerve Injury-Induced Retinal Ganglion Cell Apoptosis by Modulating the CCL5/CCR5/CTSS Axis. [PDF]

Invest Ophthalmol Vis Sci
Huang J, Chang Z, Liu L, Lai C, Deng X, Jiang B, Ke M.   +6 more
europepmc   +1 more source

Maraviroc Reduces the Regulatory T-Cell Frequency in Antiretroviral-Naive HIV-Infected Subjects

Journal of Infectious Diseases, 2014
10.1093/infdis/jiu180Maraviroc is the first antiretroviral (ART) drug to target a human protein, the CCR5 coreceptor; however, the mechanisms of maraviroc-associated immunomodulation in human immunodeficiency virus (HIV)-infected subjects remain to be ...
Ezequiel Ruiz-Mateos, Mª Ángeles Muñoz-Fernández, Yolanda M Pacheco   +2 more
exaly   +3 more sources

Asymmetric Synthesis of Maraviroc (UK-427,857)

Advanced Synthesis and Catalysis, 2010
The asymmetric synthesis of Maraviroc (UK-427,857), a chemochine receptor 5 (CCR-5) receptor antagonist, based on an expeditious organocatalytic enantioselective assembly of the chiral beta-amino aldehyde key fragment is presented.
Armando Córdova, Gui-Ling Zhao, Shuangzheng Lin   +2 more
exaly   +2 more sources

Maraviroc attenuates the pathogenesis of experimental autoimmune encephalitis

International Immunopharmacology, 2020
It has been shown that the blockade of chemokine receptor type 5 can dampen inflammatory reaction within the central nervous system (CNS). In the present study, we utilized maraviroc, a potent antagonist o CCR5, to examine whether this drug can mitigate ...
Hamid Zahednasab, Hossein Keyvani, Razieh Amini   +2 more
exaly   +1 more source

Maraviroc Can Improve Lipid Profiles in Dyslipidemic Patients with HIV: Results from the MERIT Trial

HIV Clinical Trials, 2011
"We investigated the effects of maraviroc, the first approved CC-chemokine receptor 5 (CCR5) antagonist, on blood lipids in a post hoc analysis of the phase 3 MERIT study in treatment-naive patients.
Adriano Lazzarin, H Valdez
exaly   +2 more sources

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Maraviroc Is Associated with Latent HIV-1 Reactivation through NF-κB Activation in Resting CD4+ T Cells from HIV-Infected Individuals on Suppressive Antiretroviral Therapy.

Journal of Virology, 2018
Carolina Gutiérrez, Beatriz Sastre, Santiago Moreno   +2 more
exaly