Results 1 to 10 of about 824,117 (206)

Hippocampal CCR5/RANTES Elevations in a Rodent Model of Post-Traumatic Stress Disorder: Maraviroc (a CCR5 Antagonist) Increases Corticosterone Levels and Enhances Fear Memory Consolidation [PDF]

Biomolecules, 2020
Background: Contextual fear conditioning (CFC) is a rodent model that induces a high and long-lasting level of conditioning associated with traumatic memory formation; this behavioral paradigm resembles many characteristics of posttraumatic stress ...
José Joaquín Merino, Vilma Muñetón-Gomez, César Muñetón-Gómez, María Ángeles Pérez-Izquierdo, María Loscertales, Adolfo Toledano Gasca   +5 more
doaj   +4 more sources

A CCR5 antagonist, maraviroc, alleviates neural circuit dysfunction and behavioral disorders induced by prenatal valproate exposure [PDF]

Journal of Neuroinflammation, 2022
Background Valproic acid (VPA) is a clinically used antiepileptic drug, but it is associated with a significant risk of a low verbal intelligence quotient (IQ) score, attention-deficit hyperactivity disorder and autism spectrum disorder in children when ...
Yasuhiro Ishihara, Tatsuya Honda, Nami Ishihara, Kaede Namba, Makiko Taketoshi, Yoko Tominaga, Mayumi Tsuji, Christoph F. A. Vogel, Takeshi Yamazaki, Kouichi Itoh, Takashi Tominaga   +10 more
doaj   +4 more sources

Evolution of Multiple Domains of the HIV-1 Envelope Glycoprotein during Coreceptor Switch with CCR5 Antagonist Therapy [PDF]

Microbiology Spectrum, 2022
HIV-1 uses CD4 as a receptor and chemokine receptors CCR5 and/or CXCR4 as coreceptors. CCR5 antagonists are a class of antiretrovirals used to inhibit viral entry.
Yueqi Du, Ellen Wu, Xiang Gao, Jie Zhang, John C. Martin, Bruce A. Rosa, Makedonka Mitreva, Lee Ratner   +7 more
doaj   +4 more sources

Bidirectional Action of Cenicriviroc, a CCR2/CCR5 Antagonist, Results in Alleviation of Pain-Related Behaviors and Potentiation of Opioid Analgesia in Rats With Peripheral Neuropathy [PDF]

Frontiers in Immunology, 2020
Clinical management of neuropathic pain is unsatisfactory, mainly due to its resistance to the effects of available analgesics, including opioids. Converging evidence indicates the functional interactions between chemokine and opioid receptors and their ...
Klaudia Kwiatkowski, Katarzyna Pawlik, Katarzyna Ciapała, Anna Piotrowska, Wioletta Makuch, Joanna Mika   +5 more
doaj   +3 more sources

A novel small-molecular CCR5 antagonist promotes neural repair after stroke [PDF]

Acta Pharmacologica Sinica, 2023
Nai-Hong Chen, Zhong-Ping Feng, Wen-Bin He   +2 more
exaly   +3 more sources

Discovery of a Novel CCR5 Antagonist Lead Compound Through Fragment Assembly

Molecules, 2008
CCR5, as the major co-receptor for HIV-1 entry, is an attractive novel target for the pharmaceutical industry in the HIV-1 therapeutic area. In this study, based on the structures of maraviroc and 1,4-bis(4-(7-chloroquinolin-4-yl)piperazin-1-yl)butane-1 ...
Yanqing Liu, Jian Li, Jiang Hualiang
exaly   +5 more sources

Chemokine CCR5 and cocaine interactions in the brain: Cocaine enhances mesolimbic CCR5 mRNA levels and produces place preference and locomotor activation that are reduced by a CCR5 antagonist [PDF]

Brain, Behavior, and Immunity, 2020
C-C chemokine receptor type 5, also known as CCR5 or CD195, is best known as a viral co-receptor that facilitates entry of HIV into cells. Evidence that CCR5 knockout mice display fewer dopamine neurons, lower striatal dopamine levels, and reduced ...
Stephanie Cicalese
exaly   +3 more sources

Treatment with the CCR5 antagonist OB-002 reduces lung pathology, but does not prevent disease in a Syrian hamster model of SARS-CoV-2 infection. [PDF]

PLoS ONE
Since the emergence of SARS-CoV-2 and the COVID-19 pandemic, a wide range of treatment options have been evaluated in preclinical studies and clinical trials, with several being approved for use in humans.
Bryce M Warner, Robert Vendramelli, Amrit S Boese, Jonathan Audet, Nikesh Tailor, Courtney Meilleur, Nathan Glowach, Marnie Willman, Thang Truong, Estella Moffat, Kevin Tierney, Beata Kosak, Irfan Dhanidina, Jarret Engstrom, Bozena Korczak, Ian McGowan, Carissa Embury-Hyatt, Darwyn Kobasa   +17 more
doaj   +2 more sources

Periostin-CCL3 Feedforward Signaling Loop Promotes Cardiac Fibrosis and Cardiomyocyte Necroptosis in Arrhythmogenic Cardiomyopathy. [PDF]

Adv Sci (Weinh)
POSTN‐CCL3 signaling forms a feed‐forward circuit between cardiomyocytes and cardiac myofibroblasts in arrhythmogenic cardiomyopathy. POSTN activates JNK/RIP3‐dependent necroptotic signaling and JNK/ETS2‐induced CCL3 expression in cardiomyocytes. In turn, CCL3‐CCR5 signaling in cardiac myofibroblasts activates NF‐κB/p65 and promotes POSTN expression ...
Wu T, Li R, Zhang X, Chen D, Yang J, Li M, Yin Y, Wang Y, Tian Y, Yan H, Cui D, Song J, Ouyang G.   +12 more
europepmc   +2 more sources

CCR2/CCR5 Signaling Defines a Pathogenic Interstitial Macrophage Subset That Drives Severe Asthma [PDF]

Clinical and Translational Allergy
Background Severe asthma is a chronic inflammatory disease characterised by airway dysfunction, persistent immune activation and corticosteroid resistance.
Hao Wang, Nok Him Fung, Christian Aloe, Nazanin Zounemat Kermani, Ian M. Adcock, Stavros Selemidis, Ross Vlahos, Jonathan McQualter, Steven Bozinovski   +8 more
doaj   +2 more sources