Results 21 to 30 of about 824,117 (206)

The CCR5 antagonist maraviroc exerts limited neuroprotection without improving neurofunctional outcome in experimental pneumococcal meningitis. [PDF]

Sci Rep, 2022
One-third of pneumococcal meningitis (PM) survivors suffer from neurological sequelae including learning disabilities and hearing loss due to excessive neuroinflammation.
Le ND, Steinfort M, Grandgirard D, Maleska A, Leppert D, Kuhle J, Leib SL.   +6 more
europepmc   +3 more sources

In vitro effect of anti-human immunodeficiency virus CCR5 antagonist maraviroc on chemotactic activity of monocytes, macrophages and dendritic cells

Clinical and Experimental Immunology, 2011
Compounds targeting the chemokine receptor CCR5 have recently been approved for treatment of human immunodeficiency virus (HIV) infection. Given the central role of CCR5 in inflammation and recruitment of antigen-presenting cells (APC), it is important ...
VULLO, Vincenzo, C M Mastroianni, SAUZULLO, Ilaria, MENGONI, Fabio, MASSETTI, Anna Paola, V Vullo, Rossi, R, ROSSI, RAFFAELLA, F Mengoni, A P Massetti, LICHTNER, Miriam, MASTROIANNI, Claudio Maria, R Rossi, M Lichtner, Mastroianni, C M, Lichtner, M, Sauzullo, I, Massetti, a P, I Sauzullo, DE ROSA, ANNALISA, A De Rosa, Mengoni, F, de Rosa, A, Vullo, V   +23 more
core   +2 more sources

The GHS-R Blocker D-[Lys3] GHRP-6 Serves as CCR5 Chemokine Receptor Antagonist

International Journal of Medical Sciences, 2012
[D-Lys3]-Growth Hormone Releasing Peptide-6 (DLS) is widely utilized in vivo and in vitro as a selective ghrelin receptor (GHS-R) antagonist. This antagonist is one of the most common antagonists utilized in vivo to block GHS-R function and activity ...
Kalpesh Patel, Vishwa Deep Dixit, Jun Ho Lee, Jie Wan Kim, Eric M. Schaffer, Dzung Nguyen, Dennis D. Taub
doaj   +1 more source

A New Application for Cenicriviroc, a Dual CCR2/CCR5 Antagonist, in the Treatment of Painful Diabetic Neuropathy in a Mouse Model. [PDF]

Int J Mol Sci
The ligands of chemokine receptors 2 and 5 (CCR2 and CCR5, respectively) are associated with the pathomechanism of neuropathic pain development, but their role in painful diabetic neuropathy remains unclear. Therefore, the aim of our study was to examine
Bober A, Piotrowska A, Pawlik K, Ciapała K, Maciuszek M, Makuch W, Mika J.   +6 more
europepmc   +2 more sources

V1 and V2 Domains of HIV Envelope Contribute to CCR5 Antagonist Resistance. [PDF]

J Virol, 2019
It is believed that each CCR5 antagonist-resistant isolate will develop its own unique set of mutations, making it difficult to identify a signature mutation that can effectively predict CCR5 antagonist resistance.
Wu E, Du Y, Gao X, Zhang J, Martin J, Mitreva M, Ratner L.   +6 more
europepmc   +2 more sources

Pharmacokinetics and Pharmacodynamics of TBR-652, a Novel CCR5 Antagonist, in HIV-1-Infected, Antiretroviral Treatment-Experienced, CCR5 Antagonist-Naïve Patients

Antimicrobial Agents and Chemotherapy, 2011
TBR-652 is a novel CCR5 antagonist with potent in vitro anti-HIV activity. The objective of this study was to determine the pharmacokinetics (PK) and pharmacodynamics (PD) of TBR-652 in HIV-1-infected, antiretroviral treatment ...
MyMy Trinh, Jean-Francois Marier, Sandra M. Palleja, David E. Martin, Leng Hong Pheng   +4 more
core   +2 more sources

Estimating the threshold surface density of Gp120-CCR5 complexes necessary for HIV-1 envelope-mediated cell-cell fusion. [PDF]

PLoS ONE, 2011
Reduced expression of CCR5 on target CD4(+) cells lowers their susceptibility to infection by R5-tropic HIV-1, potentially preventing transmission of infection and delaying disease progression.
Shiva Naresh Mulampaka, Narendra M Dixit
doaj   +1 more source

TGFβ1+CCR5+ neutrophil subset increases in bone marrow and causes age-related osteoporosis in male mice

Nature Communications, 2023
Age-related osteoporosis is known to be dependent on TGFβ1 signalling. Here the authors show that a subset of neutrophils (identified by TGFβ1+CCR5+) increase during aging in mouse bone marrow resulting in bone loss, while a CCR5 antagonist can reduce ...
Jinbo Li, Zhenqiang Yao, Xin Liu, Rong Duan, Xiangjiao Yi, Akram Ayoub, James O. Sanders, Addisu Mesfin, Lianping Xing, Brendan F. Boyce   +9 more
doaj   +1 more source

Inhibition of inflammatory cell infiltration by antagonistic peptides that specifically bind to CCR5 via regulation of the NF-kB signaling pathway in rats with colitis

Archives of Medical Science, 2021
Introduction CC chemokine receptor 5 (CCR5) and the NF-kB signaling pathway play important roles in the pathophysiology of inflammatory bowel disease (IBD).
Yang-Da Song, Yi-Hang Song, Si-Xue Liu, Hua-Rong Huang, Ying-Qiang Zhong   +4 more
doaj   +1 more source

CCR5 signaling promotes lipopolysaccharide-induced macrophage recruitment and alveolar developmental arrest

Cell Death and Disease, 2021
The pathogenesis of bronchopulmonary dysplasia (BPD), involves inflammatory, mechanisms that are not fully characterized. Here we report that overexpression of C-C chemokine receptor 5 (CCR5) and its ligands is associated with BPD development ...
Ze Chen, Xiaohua Xie, Na Jiang, Jianhui Li, Lei Shen, Yongjun Zhang   +5 more
doaj   +1 more source