Results 81 to 90 of about 7,681 (165)

Inhibition of dual/mixed tropic HIV-1 isolates by CCR5-inhibitors in primary lymphocytes and macrophages.

PLoS ONE, 2013
BackgroundDual/mixed-tropic HIV-1 strains are predominant in a significant proportion of patients, though little information is available regarding their replication-capacity and susceptibility against CCR5-antagonists in-vitro.
Matteo Surdo, Emanuela Balestra, Patrizia Saccomandi, Fabiola Di Santo, Marco Montano, Domenico Di Carlo, Loredana Sarmati, Stefano Aquaro, Massimo Andreoni, Valentina Svicher, Carlo Federico Perno, Francesca Ceccherini-Silberstein   +11 more
doaj   +1 more source

Prolonged administration of maraviroc reactivates latent HIV in vivo but it does not prevent antiretroviral-free viral rebound

Scientific Reports, 2020
Human immunodeficiency virus (HIV) remains incurable due to latent viral reservoirs established in non-activated CD4 T cells that cannot be eliminated via antiretroviral therapy.
María Rosa López-Huertas, Carolina Gutiérrez, Nadia Madrid-Elena, Beatriz Hernández-Novoa, Julián Olalla-Sierra, Montserrat Plana, Rafael Delgado, Rafael Rubio, María Ángeles Muñoz-Fernández, Santiago Moreno   +9 more
doaj   +1 more source

Effectiveness and cost of treatment with maraviroc in HIV infection

, 2009
Since 1995, life expectancy and quality of life of HIV patients improved significantly due to the use of Highly Active Anti-Retroviral Therapy (HAART), consisting of different combinations of three classes of antiretroviral agents, nucleoside and non ...
Pradelli, Lorenzo, Sacchi, Viola
core   +1 more source

Neurocognition with maraviroc compared with tenofovir in HIV [PDF]

, 2016
To determine whether maraviroc (MVC) has unique neurocognitive benefits in the context of initial antiretroviral therapy (ART)
Berzins, Baiba, Miyahara, Sachiko, Chan, Ellen S., Eron, Joseph J., Robertson, Kevin R., Taiwo, Babafemi O., Brown, Todd T., Rusin, David, Lee, Anthony   +8 more
core   +1 more source

Simultaneous blockade of IL-6 and CCL5 signaling for synergistic inhibition of triple-negative breast cancer growth and metastasis

Breast Cancer Research, 2018
Background Metastatic triple-negative breast cancer (TNBC) is a heterogeneous and incurable disease. Numerous studies have been conducted to seek molecular targets to treat TNBC effectively, but chemotherapy is still the main choice for patients with ...
Kideok Jin, Niranjan B. Pandey, Aleksander S. Popel   +2 more
doaj   +1 more source

The binding models for maraviroc and TAK-220.

, 2013
The binding models for maraviroc and TAK-220.
Linjie Chen (107280), Tao Liu (10785), Xiaowu Dong (107278), Ling Ma (107282), Yongzhou Hu (107289), Zhiyong Weng (107276), Shan Cen (107285), Naiming Zhou (107287)   +7 more
core   +1 more source

Spatial transcriptomics in epilepsy research: Early successes, opportunities, and challenges

Epilepsia, Volume 67, Issue 4, Page 1589-1600, April 2026.
Donald J. Phillips, Autumn S. Ivy, Samuel Guzman, Saman Hazany, Xiangmin Xu   +4 more
wiley   +1 more source

Primary resistance of CCR5-tropic HIV-1 to maraviroc cannot be predicted by the V3 sequence

, 2013
Objectives: Resistance of HIV-1 to CCR5 antagonists can occur without coreceptor switching by mutations in envelope glycoproteins that enable virus entry using the inhibitor-bound form of CCR5.
Izopet, J., Coassin, L., Cazabat, M., Saliou, A., Requena, M., Massip, P., Delobel, P., Marchou, B., Loiseau, C., Raymond, S.   +9 more
core   +1 more source

Role of Maraviroc in minimizing the risk of graft rejection in HIV-infected kidney transplant recipients

, 2020
Background Kidney transplantation in HIV-infected patients is characterized by a concerning high rate of allograft rejections. The etiological mechanisms leading to this increased immunoreactivity are still unknown.
Cappelli, Gianni, Franceschini, Erica, Alfano, Gaetano, Cristina Mussini, Erica Franceschini, Guaraldi, Giovanni, Giovanni Dolci, Dolci, Giovanni, Francesco Fontana, Gianni Cappelli, Fontana, Francesco, Mussini, Cristina, Gaetano Alfano, Giovanni Guaraldi   +13 more
core   +1 more source

A topical microbicide gel formulation of CCR5 antagonist maraviroc prevents HIV-1 vaginal transmission in humanized RAG-hu mice.

PLoS ONE, 2011
For prevention of HIV infection many currently licensed anti-HIV drugs and new ones in the pipeline show potential as topically applied microbicides. While macaque models have been the gold standard for in vivo microbicide testing, they are expensive and
C Preston Neff, Theresa Kurisu, Thomas Ndolo, Kami Fox, Ramesh Akkina   +4 more
doaj   +1 more source