Results 81 to 90 of about 480,991 (213)

Combination therapy protects macaques against advanced Marburg virus disease

Nature Communications, 2021
Monoclonal antibodies (mAbs) and remdesivir, a small-molecule antiviral, are promising monotherapies for many viruses, including members of the genera Marburgvirus and Ebolavirus (family Filoviridae), and more recently, SARS-CoV-2.
R. Cross, Z. Bornholdt, A. Prasad, V. Borisevich, K. Agans, D. Deer, Dafna M. Abelson, Do H. Kim, W. Shestowsky, L. Campbell, Elaine Bunyan, J. Geisbert, Karla A. Fenton, L. Zeitlin, D. Porter, T. Geisbert   +15 more
semanticscholar   +1 more source

Characterization of Ravn virus viral shedding dynamics in experimentally infected Egyptian rousette bats (Rousettus aegypticus)

Journal of Virology
Marburg virus (MARV) and Ravn virus (RAVV), the only two known members of the species Orthomarburgvirus marburgense (family Filoviridae), are causative agents of Marburg virus disease, a severe viral disease that typically emerges in sub-Saharan Africa ...
Jessica A. Elbert, Amy J. Schuh, Brian R. Amman, Jonathan C. Guito, James C. Graziano, Tara K. Sealy, Elizabeth W. Howerth, Jonathan S. Towner   +7 more
doaj   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Impacts of bat use of anthropogenic structures on bats and humans

Conservation Biology, EarlyView.
Abstract Human‐induced landscape modifications and climate change are forcing wildlife into closer contact with humans as the availability of natural habitats decreases. Although the importance of anthropogenic structures for the conservation of species is widely recognized, negative narratives surrounding bats may impede conservation efforts in human ...
Ella A. Sippola, Joseph S. Johnson, Stefano Mammola, Grzegorz Apoznański, Ilze Brila, Ignacio Fernández Latapiat, Piia Lundberg, Mariia Matlova, Veronica Nanni, Reilly T. Jackson, Janette Perez‐Jimenez, Sonia Sánchez‐Navarro, Elena Tena, Tanya S. Troitsky, Thomas M. Lilley, Melissa B. Meierhofer   +15 more
wiley   +1 more source

BCX4430 – A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease

Journal of Infection and Public Health, 2016
Summary: The adenosine nucleoside analog BCX4430 is a direct-acting antiviral drug under investigation for the treatment of serious and life-threatening infections from highly pathogenic viruses, such as the Ebola virus.
Raymond Taylor, Pravin Kotian, Travis Warren, Rekha Panchal, Sina Bavari, Justin Julander, Sylvia Dobo, Angela Rose, Yahya El-Kattan, Brian Taubenheim, Yarlagadda Babu, William P. Sheridan   +11 more
doaj   +1 more source

Marburg Virus Disease in Tanzania: A Review

Clinical Infection in Practice
Vaishnavi Akshay Patel, Amogh Verma, Manali Verma, Sourav Sudan, Amna Zaheer, Anil Kumar, Hajira Karim, Shubham Kumar, Rachana Mehta, Ranjana Sah   +9 more
doaj   +2 more sources

Protein nanoparticles assemble in plants, display antigenic viral peptides, and produce an epitope‐specific immune response

The FEBS Journal, EarlyView.
Current methods to control porcine reproductive and respiratory syndrome, a disease affecting pigs, are insufficient and a safer, more effective vaccine is needed. This study describes the design and plant production of a self‐assembling protein nanoparticle vaccine candidate against this disease.
Jordan T. VanderBurgt, Richard Strasser, Hong Zhu, Angelo Kaldis, Christopher P. Garnham, Rima Menassa   +5 more
wiley   +1 more source

Marburg virus disease amid COVID-19 in West Africa: an emerging and re-emerging zoonotic epidemic threat, future implications and way forward

Therapeutic Advances in Infectious Disease, 2023
Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and ...
S. Eneh, Osaretin Christabel Okonji, Anyike Goodness Chiburoma, Onukansi Francisca Ogochukwu, Levi Tuwleh, Inyangudo Gideon, E. F. Okonji, F. N. Bushabu, O. Mgbere   +8 more
semanticscholar   +1 more source

Preimaginal development of Aedes aegypti L. (Diptera: Culicidae) in brackish water gives rise to adult mosquitoes with thicker cuticles and greater insecticide resistance

Medical and Veterinary Entomology, EarlyView.
The principal arboviral vector Aedes aegypti can develop in coastal brackish water field habitats (0.5–15 g/L salt) with larvae possessing thicker cuticles and greater resistance to the larvicide Temephos. Females emerging from brackish water‐developing preimaginal stages are now shown to have thicker and remodelled leg and abdominal cuticles and ...
Kokila Sivabalakrishnan, Andrew Hemphill, S. H. P. Parakrama Karunaratne, Arunasalam Naguleswaran, Isabel Roditi, Sinnathamby N. Surendran, Ranjan Ramasamy   +6 more
wiley   +1 more source

Marburg virus pathogenesis – differences and similarities in humans and animal models

Virology Journal, 2019
Marburg virus (MARV) is a highly pathogenic virus associated with severe disease and mortality rates as high as 90%. Outbreaks of MARV are sporadic, deadly, and often characterized by a lack of resources and facilities to diagnose and treat patients ...
Kyle Shifflett, Andrea Marzi
doaj   +1 more source