Results 71 to 80 of about 6,076,506 (176)

BCX4430 – A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease

Journal of Infection and Public Health, 2016
Summary: The adenosine nucleoside analog BCX4430 is a direct-acting antiviral drug under investigation for the treatment of serious and life-threatening infections from highly pathogenic viruses, such as the Ebola virus.
Raymond Taylor, Pravin Kotian, Travis Warren, Rekha Panchal, Sina Bavari, Justin Julander, Sylvia Dobo, Angela Rose, Yahya El-Kattan, Brian Taubenheim, Yarlagadda Babu, William P. Sheridan   +11 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Refining a preclinical model of viral myocarditis in accordance with biotech standards

Animal Models and Experimental Medicine, Volume 9, Issue 9, Page 1712-1728, September 2026.
This study aimed to refine a murine model of Coxsackievirus B3‐induced myocarditis by integrating dietary and imaging innovations to improve animal welfare, data quality, and clinical applicability. The refined diet significantly reduced animal health burden, reduced weight loss, and stabilized blood glucose during development of cardiac inflammation ...
Jonas Stewen, Julia Riedesel, Juliane Stein, Brandon H. Greene, Svenja Rohde, Sonja Suess, Bjoern Keiner, Priya Panjwani, Padmapriya Ponnuswamy, Juan E. Camacho Londoño   +9 more
wiley   +1 more source

Potent immunogenicity and protective efficacy of a multi-pathogen vaccination targeting Ebola, Sudan, Marburg and Lassa viruse.

PLoS Pathogens
Viral haemorrhagic fevers (VHF) pose a significant threat to human health. In recent years, VHF outbreaks caused by Ebola, Marburg and Lassa viruses have caused substantial morbidity and mortality in West and Central Africa.
Amy Flaxman, Sarah Sebastian, Sofia Appelberg, Kuan M Cha, Marta Ulaszewska, Jyothi Purushotham, Ciaran Gilbride, Hannah Sharpe, Alexandra J Spencer, Sagida Bibi, Daniel Wright, Isabel Schmidt, Stuart Dowall, Linda Easterbrook, Stephen Findlay-Wilson, Sarah Gilbert, Ali Mirazimi, Teresa Lambe   +17 more
doaj   +1 more source

Mathematical modeling and optimal control of multi-host and environmental transmission dynamics of Marburg virus disease

Franklin Open
Marburg virus disease is a highly infectious zoonotic disease transmitted through interactions among humans, wildlife hosts, and contaminated environments, posing serious public health challenges in sub-Saharan Africa.
Ester Damiano, Jacob Ismail Irunde, Maranya Makuru Mayengo   +2 more
doaj   +1 more source

Marburg virus pathogenesis – differences and similarities in humans and animal models

Virology Journal, 2019
Marburg virus (MARV) is a highly pathogenic virus associated with severe disease and mortality rates as high as 90%. Outbreaks of MARV are sporadic, deadly, and often characterized by a lack of resources and facilities to diagnose and treat patients ...
Kyle Shifflett, Andrea Marzi
doaj   +1 more source

Mathematical Modeling of Pulse‐Seeded Metapopulation Dynamics for Andes Hantavirus Border Dispersal

Engineering Reports, Volume 8, Issue 9, September 2026.
A pulse‐seeded metapopulation SEIR model for Andes hantavirus maritime dispersal shows that heterogeneous quarantine compliance determines secondary outbreak risk. The weakest‐compliance country governs global containment, while uniform compliance above ∼65%$$ \sim 65\% $$ reduces the global reproduction number below unity.
Gideon K. Gogovi, Paul Chataa
wiley   +1 more source

Top 10 Public Health Challenges in 2025: Lessons and Priorities for 2025–2030

Public Health Challenges, Volume 5, Issue 3, September 2026.
ABSTRACT By 2025, global public health will be shaped by interconnected and intensifying threats that demand coordinated international action. Ten key public health challenges were identified and examined. This perspective reviews the challenges that shaped 2025 and the priorities set for the period 2025–2030, using evidence available up to July 2026 ...
Don Eliseo Lucero Prisno III, Mohamed Mustaf Ahmed, Zhinya Kawa Othman, Rahmatullah Nazari, Uthman Okikiola Adebayo, Olalekan John Okesanya, Shuaibu Saidu Musa, Francesco Branda, Abdullahi Hassan Elmi, Jerico Bautista Ogaya   +9 more
wiley   +1 more source

Marburg hemorrhagic fever fact sheet [last updated April 23, 2012] [PDF]

Marburg hemorrhagic fever (Marburg HF) is a rare, severe type of hemorrhagic fever which affects both humans and non-human primates. Caused by a genetically unique zoonotic (that is, animal-borne) RNA virus of the filovirus family, its recognition led to

core  

How Rwanda mounted a research response with an investigational vaccine just ten days into a Marburg outbreak

npj Vaccines
The September 2024 outbreak of Marburg virus disease (MVD) represented the first time this virus was identified in Rwanda. Health authorities mounted a rapid and effective response, including the rapid execution of an open-label Phase 2 clinical trial of
Sabin Nsanzimana, Noella Bigirimana, Richard Hatchett, Sue Bailey, Natacha Butera, Yvan Butera, Jakob P. Cramer, Amy Finan, Caroline M. Forkin, Adam M. Hacker, Sibomana Hassan, Vicky Leamy, Vincent Mutabazi, Julien Nyombayire, Eric Remera, Edson Rwagasore, Eduardo Tedeschi, Kelly L. Warfield, Nicole Lurie   +18 more
doaj   +1 more source