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Additional file 1: of Genetic assessment of inbred chicken lines indicates genomic signatures of resistance to Marekâ s disease
, 2018 Figure S1. Histogram plot of MD incidence (%) rate. MD resistance in chickens is generally evaluated with MD incidence (induced gross tumors by MDV) and survival day post MDV challenge, and the extent of resistance is dependent of the virulence of challenge viruses and other factors. Figure S2.Xu, Lingyang, He, Yanghua, Ding, Yi, Liu, George, Zhang, Huanmin, Cheng, Hans, Taylor, Robert, Song, Jiuzhou +7 moreopenaire +1 more sourceAdditional file 9: of Integrated analysis of lncRNA and mRNA repertoires in Marekâ s disease infected spleens identifies genes relevant to resistance
, 2019 Table S1. Primer sets of five candidate lncRNAs and IGF-I used in quantitative PCR analysis; QPCR gel picture of five candidate lncRNAs; (DOCX 729 kb)You, Zhen, Zhang, Qinghe, Liu, Changjun, Song, Jiuzhou, Yang, Ning, Lian, Ling +5 moreopenaire +1 more sourceAdditional file 3: of Integrated analysis of lncRNA and mRNA repertoires in Marekâ s disease infected spleens identifies genes relevant to resistance
, 2019 Figure S1. Chromosomal distribution of 1315 putative lncRNAs. 641 putative lncRNAs (48.7%) located in small scaffolds which are not shown in this figure. Chromosome Z is the second-most putative lncRNAs which has 133 putative lncRNAs (10.1%). (PDF 5 kb)You, Zhen, Zhang, Qinghe, Liu, Changjun, Song, Jiuzhou, Yang, Ning, Lian, Ling +5 moreopenaire +1 more sourceAdditional file 4: of Integrated analysis of lncRNA and mRNA repertoires in Marekâ s disease infected spleens identifies genes relevant to resistance
, 2019 Figure S2. Heatmaps of DE lncRNAs between the tumorous spleens and noninfected spleens. a the expression level of DE putative lncRNAs in each individual from the tumorous spleens and noninfected spleens. b DE known lncRNAs in each individual from the tumorous spleens and noninfected spleens. (PDF 57 kb)You, Zhen, Zhang, Qinghe, Liu, Changjun, Song, Jiuzhou, Yang, Ning, Lian, Ling +5 moreopenaire +1 more sourceToward Harmonizing Quantification of Dopamine Neuron Imaging Biomarkers in Parkinson's Disease: The Centamine Scale
Annals of Neurology, EarlyView.Objective
Dopaminergic imaging is a key biomarker for both the investigation of the biology of Parkinson's disease and related synucleinopathies and the evaluation of potential therapies in clinical trials. This work presents a harmonized approach for quantifying dopaminergic molecular imaging tracers, such as [123I]ioflupane (dopamine transporter scan Zhen Fan, Graham Searle, Gaia Rizzo, Justin Albani, Patrick Cella, Robert Comley, Gregory Klein, Luca Passamonti, Cristian Salinas, Adam J. Schwarz, Leonardo Iaccarino, Gilles Tamagnan, Jamie Eberling, Ken Marek, John Seibyl, Roger N. Gunn, The Parkinson's Progression Markers Initiative, Kenneth Marek, Caroline Tanner, Tanya Simuni, Andrew Siderowf, Douglas Galasko, Lana Chahine, Christopher Coffey, Kalpana Merchant, Kathleen Poston, Roseanne Dobkin, Tatiana Foroud, Brit Mollenhauer, Dan Weintraub, Ethan Brown, Karl Kieburtz, Mark Frasier, Todd Sherer, Sohini Chowdhury, Roy Alcalay, Aleksandar Videnovic, Duygu Tosun‐Turgut, Werner Poewe, Susan Bressman, Jan Hammer, Raymond James, Ekemini Riley, John Seibyl, Leslie Shaw, David Standaert, Sneha Mantri, Nabila Dahodwala, Michael Schwarzschild, Connie Marras, Hubert Fernandez, Ira Shoulson, Helen Rowbotham, Paola Casalin, Claudia Trenkwalder, Todd Sherer, Sohini Chowdhury, Mark Frasier, Jamie Eberling, Katie Kopil, Alyssa O'Grady, Maggie McGuire Kuhl, Leslie Kirsch, Tawny Willson, Charles Adler, Roy Alcalay, Amy Amara, Paolo Barone, Bastiaan Bloem, Susan Bressman, Kathrin Brockmann, Norbert Brüggemann, Lana Chahine, Kelvin Chou, Nabila Dahodwala, Alberto Espay, Stewart Factor, Hubert Fernandez, Michelle Fullard, Douglas Galasko, Robert Hauser, Penelope Hogarth, Shu‐Ching Hu, Michele Hu, Stuart Isaacson, Christine Klein, Rejko Krueger, Mark Lew, Zoltan Mari, Connie Marras, Maria Jose Martí, Nikolaus McFarland, Tiago Mestre, Brit Mollenhauer, Emile Moukheiber, Alastair Noyce, Njideka Okubadejo, Sarah O'Shea, Rajesh Pahwa, Nicola Pavese, Werner Poewe, Ron Postuma, Giulietta Riboldi, Lauren Ruffrage, Javier Ruiz Martinez, David Russell, Marie H Saint‐Hilaire, Neil Santos, Wesley Schlett47, Ruth Schneider, Holly Shill, David Shprecher, Tanya Simuni, David Standaert, Leonidas Stefanis, Yen Tai, Caroline Tanner, Arjun Tarakad, Eduardo Tolosa PhD34, Aleksandar Videnovic, Susan Ainscough, Courtney Blair, Erica Botting, Isabella Chung, Kelly Clark, Ioana Croitoru, Kelly DeLano, Iris Egner, Fahrial Esha, May Eshel, Frank Ferrari, Victoria Kate Foster, Alicia Garrido, Madita Grümmer, Bethzaida Herrera, Ella Hilt, Chloe Huntzinger, Raymond James, Farah Kausar, Christos Koros, Yara Krasowski60, Dustin Le, Ying Liu, Taina M. Marques, Helen Mejia Santana, Sherri Mosovsky, Jennifer Mule, Philip Ng, Lauren O'Brien, Abiola Ogunleye, Oluwadamilola Ojo, Obi Onyinanya, Lisbeth Pennente, Romina Perrotti, Michael Pileggi, Ashwini Ramachandran, Deborah Raymond, Jamil Razzaque, Shawna Reddie, Kori Ribb, Kyle Rizer, Janelle Rodriguez, Stephanie Roman, Clarissa Sanchez, Cristina Simonet, Anisha Singh, Elisabeth Sittig, Barbara Sommerfeld, Angela Stovall, Bobbie Stubbeman, Alejandra Valenzuela, Catherine Wandell, Diana Willeke, Karen Williams, Dilinuer Wubuli +174 morewiley +1 more sourceAdditional file 8: of Integrated analysis of lncRNA and mRNA repertoires in Marekâ s disease infected spleens identifies genes relevant to resistance
, 2019 Figure S3. Genomic location of three putative candidate lncRNAs and their overlapping elements. (PDF 26 kb)You, Zhen, Zhang, Qinghe, Liu, Changjun, Song, Jiuzhou, Yang, Ning, Lian, Ling +5 moreopenaire +1 more sourceThe Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding
Animal Research and One Health, EarlyView.A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT
MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen +10 morewiley +1 more sourceAdditional file 10: of Integrated analysis of lncRNA and mRNA repertoires in Marekâ s disease infected spleens identifies genes relevant to resistance
, 2019 Figure S4. Principal components analysis (PCA) of DE protein coding genes and lncRNAs in three comparisons, including DE putative lncRNAs, DE known lncRNAs, and DE protein coding genes. (PDF 64 kb)You, Zhen, Zhang, Qinghe, Liu, Changjun, Song, Jiuzhou, Yang, Ning, Lian, Ling +5 moreopenaire +1 more source