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A Review on the Marek’s Disease Outbreak and Its Virulence-Related meq Genovariation in Asia between 2011 and 2021

Animals, 2022
Marek’s disease is an infectious disease in poultry that usually appears in neural and visceral tumors. This disease is caused by Gallid alphaherpesvirus 2 infection in lymphocytes, and its meq gene is commonly used in virulent studies for coding the key
Baolin Song, Jehan Zeb, Sabir Hussain, Muhammad Umair Aziz, Elena Circella, Gaia Casalino, Antonio Camarda, Guan Yang, Nicolas Buchon, Olivier Sparagano   +9 more
doaj   +2 more sources

The dominantly expressed class II molecule from a resistant MHC haplotype presents only a few Marek's disease virus peptides by using an unprecedented binding motif.

PLoS Biology, 2021
Viral diseases pose major threats to humans and other animals, including the billions of chickens that are an important food source as well as a public health concern due to zoonotic pathogens.
Samer Halabi, Michael Ghosh, Stefan Stevanović, Hans-Georg Rammensee, Luca D Bertzbach, Benedikt B Kaufer, Martin C Moncrieffe, Bernd Kaspers, Sonja Härtle, Jim Kaufman   +9 more
doaj   +2 more sources

Pathology and Molecular Diagnosis of Marek’s Disease Virus in Chickens in Nigeria [PDF]

Scientifica
Marek’s disease caused by Marek’s disease virus (MDV) serotype 1 is an economically important neoplastic disease of poultry. Diagnosis of this disease is usually based on clinical signs, postmortem lesions, and diagnostic tests like cytology ...
Olusegun Adesina Fagbohun, Aiki-Raji Comfort Oluladun, Theophilus Aghogho Jarikre, Olugbenga Olayinka Alaka, Ademola Adetokunbo Oyagbemi, Rofiat Damilola Adesina, Oluwaseun Olanrewaju Esan, Olumide Odunayo Akinniyi, Moses Olusola Adetona, Temidayo Olutayo Omobowale, Ufuoma Joan Mamoh, Ishmael Festus Jaja   +11 more
doaj   +2 more sources

Differential Virus-Specific IFN-Gamma Producing T Cell Responses to Marek’s Disease Virus in Chickens With B19 and B21 MHC Haplotypes

Frontiers in Immunology, 2022
Marek’s disease virus (MDV), the etiologic agent for Marek’s disease (MD), causes a deadly lymphoproliferative disease in chickens. Causes of the well-documented association between genetically defined lines of chicken and resistance to MD remain unknown.
Nitish Boodhoo, Shahriar Behboudi, Shahriar Behboudi   +2 more
doaj   +2 more sources

The immune cell landscape and response of Marek’s disease resistant and susceptible chickens infected with Marek’s disease virus

Scientific Reports, 2023
Genetically resistant or susceptible chickens to Marek’s disease (MD) have been widely used models to identify the molecular determinants of these phenotypes.
Wesley C. Warren, Edward S. Rice, Ashley Meyer, Cari J. Hearn, Alec Steep, Henry D. Hunt, Melissa S. Monson, Susan J. Lamont, Hans H. Cheng   +8 more
doaj   +2 more sources

Morphological and Immunohistochemical Examination of Lymphoproliferative Lesions Caused by Marek’s Disease Virus in Breeder Chickens

Animals, 2020
Marek’s disease is widely controlled by vaccination programs; however, chickens are not totally protected, especially immediately after the vaccination when a strong challenge could interfere with the effectiveness of vaccination in the absence of proper
Alessandro Stamilla, Antonino Messina, Lucia Condorelli, Francesca Licitra, Francesco Antoci, Massimiliano Lanza, Guido Ruggero Loria, Giuseppe Cascone, Roberto Puleio   +8 more
doaj   +2 more sources

Application of lentinan in suppression of Marek's disease virus infection [PDF]

Poultry Science
Marek's disease virus (MDV) is an extremely widespread avian immunosuppressive virus. In recent years, many reports have shown that there are still cases of MDV infection and immunosuppression after immunization with the vaccine. Consequently, there is a
Qiming Gao, Kongda Zhu, Wanli Sun, Shun Li, Yixin Wang, Shuang Chang, Peng Zhao   +6 more
doaj   +2 more sources

Amino acid insertion in the Meq protein of Marek’s disease virus, an avian oncogenic herpesvirus, accelerates tumorigenesis [PDF]

Microbiology Spectrum
Marek’s disease virus (MDV) causes lymphomas (Marek’s disease) in chickens. Despite vaccination, MDV field strains exhibit increased virulence, and sporadic outbreaks are still reported.
Jumpei Sato, Shiro Murata, Yoshinosuke Motai, Shwe Yee Win, Hikari Seo, Shunsuke Yamagami, Naoya Maekawa, Tomohiro Okagawa, Satoru Konnai, Kazuhiko Ohashi   +9 more
doaj   +2 more sources

Immune escape of avian oncogenic Marek’s disease herpesvirus and antagonistic host immune responses

npj Vaccines
Marek’s disease virus (MDV) is a highly pathogenic and oncogenic alpha herpesvirus that causes Marek’s disease (MD), which is one of the most important immunosuppressive and rapid-onset neoplastic diseases in poultry.
Zhi-Jian Zhu, Man Teng, Yu Liu, Fu-Jia Chen, Yongxiu Yao, En-Zhong Li, Jun Luo   +6 more
doaj   +2 more sources

Emerging Hypervirulent Marek’s Disease Virus Variants Significantly Overcome Protection Conferred by Commercial Vaccines

Viruses, 2023
As one of the most important avian immunosuppressive and neoplastic diseases, Marek’s disease (MD), caused by oncogenic Marek’s disease virus (MDV), has caused huge economic losses worldwide over the past five decades.
Jin-ling Liu, M. Teng, Lu-Ping Zheng, F. Zhu, Shuai Ma, Lin-Yan Li, Zhi-Hui Zhang, Shu-Jun Chai, Yong-Xiu Yao, Jun Luo   +9 more
semanticscholar   +1 more source