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Borylcyclopropanes: Synthetic Strategies and Applications

Angewandte Chemie, EarlyView.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley +2 more sources

Additional file 1: of Genetic assessment of inbred chicken lines indicates genomic signatures of resistance to Marekâ s disease

, 2018
Figure S1. Histogram plot of MD incidence (%) rate. MD resistance in chickens is generally evaluated with MD incidence (induced gross tumors by MDV) and survival day post MDV challenge, and the extent of resistance is dependent of the virulence of challenge viruses and other factors. Figure S2.
Xu, Lingyang +7 more
openaire +1 more source

Additional file 3: of Integrated analysis of lncRNA and mRNA repertoires in Marekâ s disease infected spleens identifies genes relevant to resistance

, 2019
Figure S1. Chromosomal distribution of 1315 putative lncRNAs. 641 putative lncRNAs (48.7%) located in small scaffolds which are not shown in this figure. Chromosome Z is the second-most putative lncRNAs which has 133 putative lncRNAs (10.1%). (PDF 5 kb)
You, Zhen +5 more
openaire +1 more source

Additional file 8: of Integrated analysis of lncRNA and mRNA repertoires in Marekâ s disease infected spleens identifies genes relevant to resistance

, 2019
Figure S3. Genomic location of three putative candidate lncRNAs and their overlapping elements. (PDF 26 kb)
You, Zhen +5 more
openaire +1 more source

Additional file 9: of Integrated analysis of lncRNA and mRNA repertoires in Marekâ s disease infected spleens identifies genes relevant to resistance

, 2019
Table S1. Primer sets of five candidate lncRNAs and IGF-I used in quantitative PCR analysis; QPCR gel picture of five candidate lncRNAs; (DOCX 729 kb)
You, Zhen +5 more
openaire +1 more source

Additional file 4: of Integrated analysis of lncRNA and mRNA repertoires in Marekâ s disease infected spleens identifies genes relevant to resistance

, 2019
Figure S2. Heatmaps of DE lncRNAs between the tumorous spleens and noninfected spleens. a the expression level of DE putative lncRNAs in each individual from the tumorous spleens and noninfected spleens. b DE known lncRNAs in each individual from the tumorous spleens and noninfected spleens. (PDF 57 kb)
You, Zhen +5 more
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Additional file 10: of Integrated analysis of lncRNA and mRNA repertoires in Marekâ s disease infected spleens identifies genes relevant to resistance

, 2019
Figure S4. Principal components analysis (PCA) of DE protein coding genes and lncRNAs in three comparisons, including DE putative lncRNAs, DE known lncRNAs, and DE protein coding genes. (PDF 64 kb)
You, Zhen +5 more
openaire +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang +10 more
wiley +1 more source

Organelle‐Resolved Tetrazine‐trans‐Cyclooctene Click Chemistry for Cargo Delivery and Release

Chemistry – A European Journal, EarlyView.
Bioorthogonal click chemistry tools provide a means for specific intracellular conjugation of molecules. In this study, we used reactive tetrazine (Tz) and TCO moieties for labeling of organelles and organelle‐specific delivery and activation of doxorubicin prodrugs.
Oleh Durydivka +6 more
wiley +1 more source

Health System Factors in Head and Neck Cancer Diagnosis: A HEADSpAcE Consortium Qualitative Study in Glasgow and Montevideo

Head &Neck, EarlyView.
ABSTRACT Background Head and neck cancer (HNC) is a devastating diagnosis, with advanced‐stage disease leading to poorer outcomes. This qualitative study aimed to identify health system factors associated with stage of HNC diagnosis. Methods Qualitative semistructured interviews with HNC patients and clinicians were undertaken in two purposively ...
Grant Creaney +196 more
wiley +1 more source