Results 31 to 40 of about 1,311 (145)

Additional file 4: of Integrated analysis of lncRNA and mRNA repertoires in Marekâ s disease infected spleens identifies genes relevant to resistance

, 2019
Figure S2. Heatmaps of DE lncRNAs between the tumorous spleens and noninfected spleens. a the expression level of DE putative lncRNAs in each individual from the tumorous spleens and noninfected spleens. b DE known lncRNAs in each individual from the tumorous spleens and noninfected spleens. (PDF 57 kb)
You, Zhen, Zhang, Qinghe, Liu, Changjun, Song, Jiuzhou, Yang, Ning, Lian, Ling   +5 more
openaire   +1 more source

Single Cell RNA Transcriptomics of Mantle Cell Lymphoma Reveals the Presence of Treatment‐Resistant Subclones at the Time of Diagnosis

American Journal of Hematology, EarlyView.
ABSTRACT Mantle cell lymphoma (MCL) is a B‐cell malignancy with a chronically relapsing clinical course and pronounced genetic heterogeneity. To investigate the clonal dynamics underlying early disease relapse, we performed single‐cell RNA sequencing of paired tumor samples collected at diagnosis and at first relapse. Inference of copy number variants (
Dmitry Manakov, Magdalena Klanova, Michal Kolar, Robert Ivanek, Florian Geier, Julien Roux, Tomas Zikmund, Lucie Winkowska, Eva Kriegova, Jirina Manakova, Liliana Tuskova, Silvia Spanikova, Alexandra Scasna, Marek Trneny, Pavel Klener   +14 more
wiley   +1 more source

Pathology and Molecular Diagnosis of Marek’s Disease Virus in Chickens in Nigeria

Scientifica
Marek’s disease caused by Marek’s disease virus (MDV) serotype 1 is an economically important neoplastic disease of poultry. Diagnosis of this disease is usually based on clinical signs, postmortem lesions, and diagnostic tests like cytology ...
Olusegun Adesina Fagbohun, Aiki-Raji Comfort Oluladun, Theophilus Aghogho Jarikre, Olugbenga Olayinka Alaka, Ademola Adetokunbo Oyagbemi, Rofiat Damilola Adesina, Oluwaseun Olanrewaju Esan, Olumide Odunayo Akinniyi, Moses Olusola Adetona, Temidayo Olutayo Omobowale, Ufuoma Joan Mamoh, Ishmael Festus Jaja   +11 more
doaj   +1 more source

A novel method for genome-wide profiling of dynamic host-pathogen interactions using 3′ end enriched RNA-seq

Scientific Reports, 2017
Marek’s disease is a contagious lymphoproliferative disease of chickens and typical model of viral oncogenesis. Mapping changes or different states over the course of infection for both host and pathogen would provide important insights into dynamic host-
Jie Li, Liangliang He, Yun Zhang, Chunyi Xue, Yongchang Cao   +4 more
doaj   +1 more source

Additional file 8: of Integrated analysis of lncRNA and mRNA repertoires in Marekâ s disease infected spleens identifies genes relevant to resistance

, 2019
Figure S3. Genomic location of three putative candidate lncRNAs and their overlapping elements. (PDF 26 kb)
You, Zhen, Zhang, Qinghe, Liu, Changjun, Song, Jiuzhou, Yang, Ning, Lian, Ling   +5 more
openaire   +1 more source

Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats

Animal Models and Experimental Medicine, EarlyView.
Genetically uniform Zucker Diabetic Fatty (ZDF) rats spontaneously develop four distinct metabolic phenotypes despite identical housing and diet conditions. Each phenotype exhibits unique biomarker signatures encompassing glucose homeostasis, insulin secretion, polyol pathway activation, oxidative stress, inflammatory cytokines, and neurotrophic ...
Marek Lepáček, Pavol Boďo, Barbora Kaločayová, Marta Šoltésová Prnová   +3 more
wiley   +1 more source

Additional file 10: of Integrated analysis of lncRNA and mRNA repertoires in Marekâ s disease infected spleens identifies genes relevant to resistance

, 2019
Figure S4. Principal components analysis (PCA) of DE protein coding genes and lncRNAs in three comparisons, including DE putative lncRNAs, DE known lncRNAs, and DE protein coding genes. (PDF 64 kb)
You, Zhen, Zhang, Qinghe, Liu, Changjun, Song, Jiuzhou, Yang, Ning, Lian, Ling   +5 more
openaire   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Deletion of the meq gene significantly decreases immunosuppression in chickens caused by pathogenic marek's disease virus

Virology Journal, 2011
Background Marek's disease virus (MDV) causes an acute lymphoproliferative disease in chickens, resulting in immunosuppression, which is considered to be an integral aspect of the pathogenesis of Marek's disease (MD).
Cui Zhizhong, Zhao Peng, Su Shuai, Sun Aijun, Li Yanpeng, Zhu Hongfei   +5 more
doaj   +1 more source

Histone methylation analysis and pathway predictions in chickens after MDV infection. [PDF]

PLoS ONE, 2012
Marek's disease (MD) is a lymphoproliferative disease in chicken induced by Marek's disease virus (MDV). Although studies have focused on the genetic differences between the resistant and susceptible chicken, less is known about the role of epigenetic ...
Juan Luo, Apratim Mitra, Fei Tian, Shuang Chang, Huanmin Zhang, Kairong Cui, Ying Yu, Keji Zhao, Jiuzhou Song   +8 more
doaj   +1 more source