Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective [PDF]
, 2019 Unregulated acute inflammation can lead to collateral tissue injury in vital organs, such as the lung during the acute respiratory distress syndrome.
Dalli, Jesmond +9 more
core +1 more source
Maresin 1 protects the liver against ischemia/reperfusion injury via the ALXR/Akt signaling pathway
Molecular Medicine, 2021 Background Hepatic ischemia/reperfusion (I/R) injury can be a major complication following liver surgery contributing to post-operative liver dysfunction. Maresin 1 (MaR1), a pro-resolving lipid mediator, has been shown to suppress I/R injury.
Da Tang +7 more
doaj +1 more source
The relationship between hepatocellular carcinoma and maresin 1 [PDF]
, 2021 Tıp Fakültesi, İç Hastalıkları Ana Bilim DalıGiriş ve Amaç: Karaciğer kanseri, kansere bağlı ölümlerde 4. sıradadır ve hepatoselüler karsinom (HCC), karaciğerin en sık görülen primer malign tümörüdür.
Yücel, Ayşe
core
European review for medical and pharmacological sciences, 2023 Cerebrovascular diseases (CVDs) remain an important public health issue due to the increasing number of deaths worldwide. Changes in the synthesis and release of peptides in CVDs may play an important role in elucidating the physiopathology of the disease. Therefore, this study was to investigate the fate of maresin-1 (MaR-1), subfatin (SUB), asprosin (
Albayrak, S. +9 more
openaire +2 more sources
Maresin 1 Biosynthesis and Proresolving Anti-infective Functions with Human-Localized Aggressive Periodontitis Leukocytes [PDF]
, 2019 Localized aggressive periodontitis (LAP) is a distinct form of early-onset periodontitis linked to periodontal infection with uncontrolled inflammation and leukocyte-mediated tissue destruction.
Chiang, Nan +8 more
core +1 more source
Maresin-like Lipid Mediators Are Produced by Leukocytes and Platelets and Rescue Reparative Function of Diabetes-Impaired Macrophages [PDF]
, 2014 SummaryNonhealing diabetic wounds are associated with impaired macrophage (Mf) function. Leukocytes and platelets (PLT) play crucial roles in wound healing by poorly understood mechanisms.
Laborde, James Monroe +6 more
core +1 more source
Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators [PDF]
, 2020 Human reticulocyte 15-lipoxygenase-1 (h15-LOX-1 or ALOX15) and platelet 12-lipoxygenase (h12-LOX or ALOX12) catalysis of docosahexaenoic acid (DHA) and the maresin precursor, 14S-hydroperoxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid (14S-HpDHA), were ...
Tourdot, Benjamin E +7 more
core +1 more source
Neural Regeneration ResearchSpecialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer’s disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer’s disease to prevent/stop ...
Ying Wang +8 more
doaj +1 more source
Peripheral targets for neuropathic pain
British Journal of Pharmacology, EarlyView.Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour +3 more
wiley +1 more source
Maresin 1 regulates peripheral leukocyte responses in patients with chronic eosinophilic nasal polyposis [PDF]
, 2023 The discovery of specialized pro-resolving mediators (SPM) has changed our understanding of inflammation leading to an appreciation for the role of dysregulated SPM pathways in chronic disease.
Beegun, I
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