Results 91 to 100 of about 21,237,081 (159)

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, Volume 13, Issue 34, 19 June 2026.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source

Differential Effects of Benralizumab and Mepolizumab on Pro‐Resolving Mediators

Allergy, EarlyView.
Jaime Bernaola, José Antonio Cañas, Álvaro Arranz‐Fragua, José Manuel Rodrigo‐Muñoz, Daniel Rodríguez‐González, Antonio Serrano‐Santiago, Gema Guillén‐Sánchez, Alma Martínez Fernández, Marcela Valverde‐Monge, Diana Betancor, Erwin Javier Pinillos‐Robles, Claudia Rodríguez‐Busto, María Jesús Rodríguez‐Nieto, Joaquín Sastre, Victoria del Pozo   +14 more
wiley   +1 more source

Microalgae Oil Attenuates Liver Fat Deposition in NAFLD via Modulation of Anti‐Lipogenic Genes and Insulin Signaling Pathways in HFD Mice

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Dietary microalgae oil might reverse hepatic lipid deposition in a mouse model of fatty liver. This intervention significantly improves the overall fatty liver condition by reducing lipid accumulation and simultaneously restoring insulin sensitivity. ABSTRACT Non‐alcoholic fatty liver disease (NAFLD) is a leading cause of liver‐related mortality and ...
Athba AlQahtani, Mingjie Wang, Liping Liu, Liyuan Ran, Chao Liu, Yun Liang, Jinhui Yu, Yingjie Wu, Qingbo Guan   +8 more
wiley   +1 more source

Maresin 1 Resolves Inflammation and Aids Bone Healing in Periapical Lesions

Journal of Dental Research
Chronic apical periodontitis (CAP) is a persistent inflammatory condition caused by microbial infections in the root canal system, leading to bone loss and tissue damage. In this study, we tested the hypothesis that maresin 1 (MaR1), a specialized proresolving mediator, facilitates inflammatory resolution and promotes bone healing ...
E. Demir, I. İlgenli, Z. Guney, S. Mohammadi, K. Lauwens, N. Yakar, C. Alvarez Rivas, O. Unlu, A. Kantarci   +8 more
openaire   +2 more sources

Efficacy of omega‐3 fatty acids as a functional food: a multifaceted approach to health reinforcement

Journal of the Science of Food and Agriculture, Volume 106, Issue 8, Page 4521-4549, June 2026.
Abstract Omega‐3 fatty acids (omega‐3s) are polyunsaturated fatty acids linked with numerous health benefits. Omega‐3s exhibit multifaceted activities through various mechanisms. Eicosapentaenoic acid (EPA) alleviates oxidative stress by lowering reactive oxygen species and improving oxidative stress in brain tissues and acts against neurodegenerative ...
Md Faruque Ahmad, Abdulrahman A Alsayegh, Anjum Khanam, Awais Ahmed, António Raposo, Farkad Bantun, Md Zeyaullah, Ahmad O Babalghith, Abdullah F Aldairi, Boshra Mozaffar, Mohammed F Bajahzer, Mohamed H Abdelrahman, Mohammad Intakhab Alam   +12 more
wiley   +1 more source

Fatty Acid Metabolism in Health and Cancer: From Fundamental Mechanisms to Therapeutic Application

MedComm, Volume 7, Issue 6, June 2026.
The modulation of the TME by fatty acid metabolism primarily occurs through four key pathways: inflammation regulation, signal transduction, translation to TME, and oxidative stress. ABSTRACT Fatty acid metabolism (FAM) plays a vital role in maintaining health by supporting energy production, cellular structure, and signaling processes.
Na Hang, Runkang Zhao, Fan Zhang, Dandan Guo, Qing Li, Zhijun Shen, Ruiqing Gao, Chenyu Gao, Zhao Xie, Sentao Fu, Peng Luo, Bufu Tang, Ling Wang   +12 more
wiley   +1 more source

Maresin 1 Improves Cognitive Decline and Ameliorates Inflammation in a Mouse Model of Alzheimer’s Disease

Frontiers in Cellular Neuroscience, 2019
Alzheimer’s disease (AD) is one of the most common neurodegenerative disease. Accumulating evidences suggest an active role of inflammation in the pathogenesis of AD.
Ping Yin, Ping Yin, Xu Wang, Shuang Wang, Yafen Wei, Yafen Wei, Jiachun Feng, Mingqin Zhu   +7 more
doaj   +1 more source

Omega‐3 DHA as a blank canvas: A molecular approximation to how lipid mediators modulate LGR6 in inflammation resolution

Protein Science, Volume 35, Issue 6, June 2026.
Abstract The leucine‐rich repeat‐containing G protein‐coupled receptor 6 (LGR6) has a potential role in inflammation resolution and different cancer processes. In this study, we employed computational techniques, including molecular docking and molecular dynamics simulations of mammalian membrane‐embeded systems, to understand the activation mechanism ...
Álex Pérez‐Sánchez, Mireia Garcia‐Viloca, Àngels González‐Lafont, José M. Lluch   +3 more
wiley   +1 more source

The specialized pro-resolving lipid mediator maresin 1 protects hepatocytes from lipotoxic and hypoxia-induced endoplasmic reticulum stress. [PDF]

, 2019
Endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) are hallmarks of nonalcoholic fatty liver disease (NAFLD), which is the hepatic manifestation of the metabolic syndrome associated with obesity.
Rius, Bibiana, Titos Rodríguez, Esther, López Vicario, Cristina, Casulleras, Mireia, Duran Güell, Marta, Alcaraz-Quiles, José, Lopategi, Aritz, Lozano Salvatella, Juan José, Flores Costa, Roger, Clària i Enrich, Joan   +9 more
core   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, Volume 13, Issue 29, 22 May 2026.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source