Results 101 to 110 of about 1,753 (134)

Maresin-1 promotes neuroprotection and modulates metabolic and inflammatory responses in disease-associated cell types in preclinical models of multiple sclerosis. [PDF]

J Biol Chem
Zahoor I, Nematullah M, Ahmed ME, Fatma M, Sajad M, Ayasolla K, Cerghet M, Palaniyandi S, Ceci V, Carrera G, Buttari F, Centonze D, Mao-Draayer Y, Rattan R, Chiurchiù V, Giri S.   +15 more
europepmc   +1 more source

Maresin 1 alleviates neuroinflammation and cognitive decline in a mouse model of cecal ligation and puncture. [PDF]

Zhong Nan Da Xue Xue Bao Yi Xue Ban
Li L, Xing M, Wang L, Zhao Y.
europepmc   +1 more source

The Specialized Proresolving Mediator Maresin 1 Alleviated Neuropathic Pain Exacerbated by High-Fat Diet via Regulating Neuroinflammation

Pain Research and Management
Li Zhang, Ran Hu, Kexin Qin, Xue Wang, Chen Wu, Zichen Liu, Xiangqi Shao, Jianru Sun, Yang Liu, Saisong Xiao, Huilong Ren, Fan Liu, Guokai Liu   +12 more
doaj   +1 more source

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Maresin-1 resolution with RORα and LGR6

Progress in Lipid Research, 2020
Maresin-1, a pro-resolving lipid mediator, is drawing a great deal of attention in receptor pharmacology, largely because two distinct types of receptor molecules have been reported as the targets of maresin-1. One is retinoic acid-related orphan receptor α (RORα) and the other is leucine-rich repeat domain-containing G protein-coupled receptor 6 (LGR6)
Dong-Soon Im
exaly   +3 more sources

Stereoselective synthesis of maresin 1

Tetrahedron Letters, 2015
Abstract Maresin 1 is a potent anti-inflammatory and pro-resolving lipid mediator derived from docosahexaenoic acid. The total synthesis of maresin 1 is achieved in 10 steps and in 7% overall yield. The Evans–Nagao aldol reaction between (2E,4E)-5-bromopenta-2,4-dienal and different chiral auxiliaries is investigated.
Trond Vidar Hansen, Marius Aursnes
exaly   +2 more sources

Synthesis of maresin 1 and (7S)-isomer

Tetrahedron Letters, 2014
Maresin 1 (with the 7R carbon) and (7S)-maresin 1 were synthesized stereoselectively. The conjugated triene system was constructed by Pd-catalyzed coupling of the trans cis-dienylborane (the C10–C22 part) with the trans vinyl iodide corresponding to the C1–C9 part.
Narihito Ogawa, Yuichi Kobayashi
exaly   +2 more sources

Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2014
Significance Neutrophil accumulation is fundamental to acute inflammation. In response to tissue injury, circulating neutrophil–platelet aggregates (N-PAs) form for secondary capture. Counterregulation of acute inflammatory processes by specialized proresolving mediators is essential to mitigate collateral injury to healthy bystander ...
Jesmond Dalli, Bruce David Levy, Nandini Krishnamoorthy   +2 more
exaly   +5 more sources

Maresin 1 intervention reverses experimental pulmonary arterial hypertension in mice

British Journal of Pharmacology, 2022
Background and PurposePulmonary arterial hypertension (PAH) is a pulmonary vasculature obstructive disease that leads to right heart failure and death. Maresin 1 is an endogenous lipid mediator known to promote inflammation resolution. However, the effect of Maresin 1 on PAH remains unclear.Experimental ApproachThe serum Maresin 1 concentration was ...
Aaron Scott, Hui Li
exaly   +3 more sources

Relationship between pancreatic cancer and Maresin 1

Journal of Current Hematology & Oncology Research, 2023
Aims: Pancreatic cancer is the 4th most common cause of death from cancer. In addition, pancreatic cancer is the most common primary malignant tumor of the pancreas. There are many risk factors for pancreatic cancer, including age, certain genetic syndromes, smoking, diabetes, alcohol abuse and obesity.
Hakan Varol, Özlem Gül, Bilal Ergül, Üçler Kısa, Ercan Tekin, Dilek Oğuz   +5 more
openaire   +1 more source

Maresin-1 induces cardiomyocyte hypertrophy through IGF-1 paracrine pathway

American Journal of Physiology - Cell Physiology, 2021
The resolution of inflammation is closely linked with tissue repair. Recent studies have revealed that macrophages suppress inflammatory reactions by producing lipid mediators, called specialized proresolving mediators (SPMs); however, the biological significance of SPMs in tissue repair remains to be fully elucidated in the heart.
Tri Wahyuni, Anton Bahtiar, Masanori Obana   +2 more
exaly   +3 more sources