Differential Effects of Marimastat and Prinomastat on the Metalloprotease Activity of Various Snake Venoms [PDF]
ToxinsSnakebite envenoming is a neglected tropical disease, responsible for approximately 140,000 deaths globally each year. Vipers and elapid snakes represent the most significant snake families in medical contexts, exhibiting a variety of venom components ...
Mahtab Khatibi +6 more
doaj +5 more sources
Pulmonary delivery of the broad-spectrum matrix metalloproteinase inhibitor marimastat diminishes multiwalled carbon nanotube-induced circulating bioactivity without reducing pulmonary inflammation [PDF]
Particle and Fibre Toxicology, 2021 Background Multiwalled carbon nanotubes (MWCNT) are an increasingly utilized engineered nanomaterial that pose the potential for significant risk of exposure-related health outcomes.
Tamara L. Young +13 more
doaj +2 more sources
Repurposing Cancer Drugs Batimastat and Marimastat to Inhibit the Activity of a Group I Metalloprotease from the Venom of the Western Diamondback Rattlesnake, Crotalus atrox [PDF]
Toxins, 2020 Snakebite envenomation causes over 140,000 deaths every year, predominantly in developing countries. As a result, it is one of the most lethal neglected tropical diseases. It is associated with incredibly complex pathophysiology due to the vast number of
Harry J. Layfield +12 more
doaj +2 more sources
Mechanical Stretch‐Induced Interlayer Coordination between MMP2 and COL17A1 Exacerbates Regenerative Exhaustion in Skin [PDF]
Advanced ScienceThe layered structure of skin necessitates highly sophisticated tissue coordination during regeneration. The unmet clinical need of long‐term skin expansion therapy stems from limited regenerative capacity, yet the underlying mechanism remains enigmatic ...
Yidan Sun +13 more
doaj +2 more sources
Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms [PDF]
Nature Communications, 2023 Morbidity from snakebite envenoming affects approximately 400,000 people annually. Tissue damage at the bite-site often leaves victims with catastrophic life-long injuries and is largely untreatable by current antivenoms.
Steven R. Hall +9 more
doaj +2 more sources
Marimastat inhibits neointimal thickening in a model of human vein graft stenosis [PDF]
Journal of British Surgery, 1998 Abstract Background There is now accumulating evidence that matrix metalloproteinases (MMPs), the physiological mediators of matrix deposition and degradation, play an important role in the development of intimal hyperplasia following arterial bypass.
Karen E. Porter +5 more
openalex +4 more sources
Demonstration of the Anthelmintic Potency of Marimastat in the Heligmosomoides polygyrus Rodent Model [PDF]
Journal of Parasitology, 2018 In the course of a structure based drug discovery program the known anticancer candidate marimastat was uncovered as a potent inhibitor of an enzyme in nematode cuticle biogenesis. It was shown to kill Caenorhabditis elegans, and the sheep parasites Haemonchus contortus and Teladorsagia circumcinta via an entirely novel nematode-specific pathway ...
Erle S. Robertson +6 more
openalex +5 more sources
A phase II trial of marimastat in advanced pancreatic cancer [PDF]
British Journal of Cancer, 2001 Pancreatic cancer has a poor response to conventional chemotherapy and radiotherapy. Inhibition of matrix metalloproteinase activity involved in tumour invasion and metastases is a novel biological approach for cancer treatment. This multicentre phase II clinical trial assessed marimastat, an oral matrix metalloproteinase inhibitor, in patients with ...
James D. Evans +8 more
openalex +4 more sources
Matrix Metalloproteinase Inhibitor, Marimastat, Decreases Peritoneal Spread of Gastric Carcinoma in Nude Mice [PDF]
Japanese Journal of Cancer Research, 2002 Marimastat, a matrix metalloproteinese inhibitor, was examined for the ability to prevent peritoneal dissemination of a human gastric cancer xenograft, TMK–1. Even with novel approaches such as molecular targeting of cancer chemotherapy, peritoneal dissemination of gastric cancer has little sensitivity to anticancer drugs, and it is impossible to ...
Masaru Kimata +11 more
openalex +3 more sources
Identification of Differential Metabolites in Chronic Suppurative Otitis Media With Non‐Targeted and Targeted Metabolomics Approach [PDF]
Smart MedicineChronic suppurative otitis media (CSOM) is a leading cause of hearing loss and otorrhea, and when associated with cholesteatoma, it can pose a serious threat to patients' lives.
Lidan Hu +9 more
doaj +2 more sources