Results 41 to 50 of about 2,105 (188)

Marimastat

, 2008
openaire   +2 more sources

In vivo Efficacy of Marimastat and Chemoradiation in Head and Neck Cancer Xenografts [PDF]

ORL, 2008
<i>Objective:</i> To assess the effect of combining a synthetic matrix metalloprotease inhibitor and chemoradiation therapy on tumor growth in a murine model of head and neck squamous-cell carcinoma (SCC). <i>Methods:</i> Athymic, nude mice bearing SCC-1 xenografts were used to comprise 4 treatment groups: (1) control receiving ...
Joni B, Skipper, Lacey R, McNally, Eben L, Rosenthal, Wenquan, Wang, Donald J, Buchsbaum   +4 more
openaire   +2 more sources

Melanoma Mediated Disruption of Brain Endothelial Barrier Integrity Is Not Prevented by the Inhibition of Matrix Metalloproteinases and Proteases

Biosensors, 2022
We have previously shown that human melanoma cells rapidly decrease human brain endothelial barrier strength. Our findings showed a fast mechanism of melanoma mediated barrier disruption, which was localised to the paracellular junctions of the brain ...
Akshata Anchan, Graeme Finlay, Catherine E. Angel, James J. W. Hucklesby, E. Scott Graham   +4 more
doaj   +1 more source

Profiling the immune response to anti‐Aβ immunotherapy [PDF]

Alzheimers Dement
Abstract Background As patients receive approved anti‐Aβ immunotherapies the critical need to understand the effects of anti‐Aβ antibody exposure on the brain is of extreme priority. We sought to identify immune changes in response to acute and chronic anti‐Aβ antibody to determine potential causes of neuroinflammation that may lead to ARIA (amyloid ...
Foley K, Krick K, Weekman E, Wilcock D.
europepmc   +2 more sources

Marimastat treatment increased hepatic fibrosis following repeated carbon tetrachloride (CCl4) administration.

, 2013
In mice treated with Marimastat, the liver to body weight ratio (A), as well as the spleen to body weight ratio (B) were increased. Masson trichrome staining of liver sections for collagen (blue; C) revealed bridging portal fibrosis.
Hau D. Le (343378), Vincent E. de Meijer (343377), Deanna Y. Sverdlov (363722), Yury Popov (343381), Detlef Schuppan (204756), Vânia Nosé (5653522), Mark Puder (343382), Jonathan A. Meisel (343379)   +7 more
core   +1 more source

Marimastat decreases hepatic stellate cell (HSC) activation, but increases recruitment of inflammatory cells.

, 2013
Chronic carbon tetrachloride (CCl4) administration in animals treated with Marimastat resulted in a decreased activation of HSCs, as identified by alpha-smooth muscle actin (α-SMA) staining (A).
Hau D. Le (343378), Vincent E. de Meijer (343377), Deanna Y. Sverdlov (363722), Yury Popov (343381), Detlef Schuppan (204756), Vânia Nosé (5653522), Mark Puder (343382), Jonathan A. Meisel (343379)   +7 more
core   +1 more source

Marimastat treatment downregulates matrix metalloproteinase (MMP) gene expression and MMP-activities.

, 2013
Following repeated carbon tetrachloride (CCl4) administration, Marimastat did not affect hepatic transcript levels of MMP-2 (A), or MMP-3 (B) as quantified by real-time RT-PCR. Hepatic MMP-8 (C) and MMP-9 (D) transcripts were significantly upregulated in
Hau D. Le (343378), Vincent E. de Meijer (343377), Deanna Y. Sverdlov (363722), Yury Popov (343381), Detlef Schuppan (204756), Vânia Nosé (5653522), Mark Puder (343382), Jonathan A. Meisel (343379)   +7 more
core   +1 more source

The Matrix Metalloproteinase Inhibitor Marimastat Promotes Neural Progenitor Cell Differentiation into Neurons by Gelatinase-Independent TIMP-2-Dependent Mechanisms

, 2013
Metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs), produced in the brain by cells of non-neural and neural origin, including neural progenitors (NPs), are emerging as regulators of nervous system development and adult brain functions.
Medda, Virginia, Minghetti, Luisa, Sinno, Maddalena, Maddalena Sinno, Pasquale Caramanica, Luisa Minghetti, Virginia Medda, Maria Antonietta Ajmone Cat, CACCI, Emanuele, Gaetana Tonti, Ajmone-Cat, Maria Antonietta, BIAGIONI, Stefano, Tonti, Gaetana, Caramanica, Pasquale, PAFUMI, IRENE, Mannello, Ferdinando, Ferdinando Mannello   +16 more
core   +2 more sources

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, Volume 13, Issue 49, 3 September 2026.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Clinical management of snakebite envenoming: Future perspectives

Toxicon: X, 2021
Snakebite envenoming is a major cause of morbidity and mortality in rural communities throughout the tropics. Generally, the main clinical features of snakebites are local swelling, tissue necrosis, shock, spontaneous systemic hemorrhage, incoagulable ...
Muhammad Hamza, Cecilie Knudsen, Christeine Ariaranee Gnanathasan, Wuelton Monteiro, Matthew R. Lewin, Andreas H. Laustsen, Abdulrazaq G. Habib   +6 more
doaj   +1 more source