Results 1 to 10 of about 465 (96)

Differential Effects of Marimastat and Prinomastat on the Metalloprotease Activity of Various Snake Venoms [PDF]

Toxins
Snakebite envenoming is a neglected tropical disease, responsible for approximately 140,000 deaths globally each year. Vipers and elapid snakes represent the most significant snake families in medical contexts, exhibiting a variety of venom components ...
José Rafael de Almeida, Sakthivel Vaiyapuri, Ketan Patel   +2 more
exaly   +6 more sources

Extreme Procoagulant Potency in Human Plasma of Venoms from the African Viperid Genera Atheris, Cerastes, and Proatheris and the Relative Efficacy of Antivenoms and Synthetic Enzyme-Inhibitors [PDF]

Toxins, 2022
The African viperid snake genera Atheris, Cerastes, and Proatheris are closely related, similar in size, but occupy extremely divergent ecological niches (arboreal in tropical rainforests, fossorial in deserts, and swamp-dwelling, respectively).
Abhinandan Chowdhury, Matthew R. Lewin, Rebecca Carter, Raul Soria, Matt Aldridge, Bryan G. Fry   +5 more
doaj   +2 more sources

Efficacy and Limitations of Chemically Diverse Small-Molecule Enzyme-Inhibitors against the Synergistic Coagulotoxic Activities of Bitis Viper Venoms [PDF]

Molecules, 2022
Snakebite remains a significant public health burden globally, disproportionately affecting low-income and impoverished regions of the world. Recently, researchers have begun to focus on the use of small-molecule inhibitors as potential candidates for ...
Nicholas J. Youngman, Matthew R. Lewin, Rebecca Carter, Arno Naude, Bryan G. Fry   +4 more
doaj   +2 more sources

In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus [PDF]

Toxicon: X, 2022
Snakebite envenoming affects more than 250,000 people annually in sub-Saharan Africa. Envenoming by Dispholidus typus (boomslang) results in venom-induced consumption coagulopathy (VICC), whereby highly abundant prothrombin-activating snake venom ...
Stefanie K. Menzies, Rachel H. Clare, Chunfang Xie, Adam Westhorpe, Steven R. Hall, Rebecca J. Edge, Jaffer Alsolaiss, Edouard Crittenden, Amy E. Marriott, Robert A. Harrison, Jeroen Kool, Nicholas R. Casewell   +11 more
doaj   +2 more sources

The Relative Efficacy of Chemically Diverse Small-Molecule Enzyme-Inhibitors Against Anticoagulant Activities of African Spitting Cobra (Naja Species) Venoms [PDF]

Frontiers in Immunology, 2021
African spitting cobras are unique among cobras for their potent anticoagulant venom activity arising from strong inhibition of Factor Xa. This anticoagulant effect is exerted by venom phospholipase A2 (Group I PLA2) toxins whose activity contributes to ...
Abhinandan Chowdhury, Abhinandan Chowdhury, Matthew R. Lewin, Matthew R. Lewin, Christina N. Zdenek, Rebecca Carter, Bryan G. Fry   +6 more
doaj   +2 more sources

Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike Protein [PDF]

mBio, 2022
The ongoing global vaccination program to prevent SARS-CoV-2 infection, the causative agent of COVID-19, has had significant success. However, recently, virus variants that can evade the immunity in a host achieved through vaccination have emerged ...
Mizuki Yamamoto, Jin Gohda, Ayako Kobayashi, Keiko Tomita, Youko Hirayama, Naohiko Koshikawa, Motoharu Seiki, Kentaro Semba, Tetsu Akiyama, Yasushi Kawaguchi, Jun-ichiro Inoue   +10 more
doaj   +2 more sources

Soluble Sema4D cleaved from osteoclast precursors by TACE suppresses osteoblastogenesis. [PDF]

J Cell Mol Med, 2023
Abstract Bone remodelling is mediated by orchestrated communication between osteoclasts and osteoblasts which, in part, is regulated by coupling and anti‐coupling factors. Amongst formally known anti‐coupling factors, Semaphorin 4D (Sema4D), produced by osteoclasts, plays a key role in downmodulating osteoblastogenesis.
Ishii T, Ruiz-Torruella M, Kim JY, Kanzaki H, Albassam A, Wisitrasameewong W, Shindo S, Pierrelus R, Heidari A, Kandalam U, Nakamura S, Movila A, Minond D, Kawai T.   +13 more
europepmc   +2 more sources

Venom-Induced Blood Disturbances by Palearctic Viperid Snakes, and Their Relative Neutralization by Antivenoms and Enzyme-Inhibitors [PDF]

Frontiers in Immunology, 2021
Palearctic vipers are medically significant snakes in the genera Daboia, Macrovipera, Montivipera, and Vipera which occur throughout Europe, Central Asia, Near and Middle East.
Abhinandan Chowdhury, Abhinandan Chowdhury, Christina N. Zdenek, Matthew R. Lewin, Matthew R. Lewin, Rebecca Carter, Tomaž Jagar, Erika Ostanek, Hannah Harjen, Matt Aldridge, Raul Soria, Grace Haw, Bryan G. Fry   +12 more
doaj   +2 more sources

Photodynamic Therapy Targeting Matrix Metalloproteases in Cancer: Standpoint for an Innovative Anticancer Strategy [PDF]

Current Issues in Molecular Biology
Matrix metalloproteases (MMPs), which are activated during malignancy growth and metastasis, have been a focus of current anticancer research and development. The selective recognition and precise inhibition of active MMPs could limit cancer progression.
Vanya Mantareva, Diana Braikova, Mingna Sun, Jianye Zhang   +3 more
doaj   +2 more sources

When proteases reshape barriers: Basement membrane remodelling in development, wound healing and tumour progression. [PDF]

FEBS J
Basement membrane (BM) homeostasis relies on a balance between integrity, controlled remodelling and pathological degradation. Increased protease expression beneath the BM, along with reduced levels of endogenous protease inhibitors, drives the transition from a continuous, protective barrier to a discontinuous interface.
Legendre C, Dayan G, Rousselle P.
europepmc   +2 more sources