Results 11 to 20 of about 510 (116)

Differential effects of the venoms of Russell’s viper and Indian cobra on human myoblasts [PDF]

Scientific Reports
Local tissue damage following snakebite envenoming remains a poorly researched area. To develop better strategies to treat snakebites, it is critical to understand the mechanisms through which venom toxins induce envenomation effects including local ...
Husain Bin Haidar, José R. Almeida, Jarred Williams, Bokai Guo, Anne Bigot, Subramanian Senthilkumaran, Sakthivel Vaiyapuri, Ketan Patel   +7 more
doaj   +3 more sources

Differential Antivenom and Small-Molecule Inhibition of Novel Coagulotoxic Variations in Atropoides, Cerrophidion, Metlapilcoatlus, and Porthidium American Viperid Snake Venoms [PDF]

Toxins, 2022
Within Neotropical pit-vipers, the Mexican/Central-American clade consisting of Atropoides, Cerrophidion, Metlapilcoatlus, and Porthidium is a wide-ranging, morphologically and ecologically diverse group of snakes.
Lee Jones, Nicholas J. Youngman, Edgar Neri-Castro, Alid Guadarrama-Martínez, Matthew R. Lewin, Rebecca Carter, Nathaniel Frank, Bryan G. Fry   +7 more
doaj   +3 more sources

A Clot Twist: Extreme Variation in Coagulotoxicity Mechanisms in Mexican Neotropical Rattlesnake Venoms [PDF]

Frontiers in Immunology, 2021
Rattlesnakes are a diverse clade of pit vipers (snake family Viperidae, subfamily Crotalinae) that consists of numerous medically significant species.
Lorenzo Seneci, Lorenzo Seneci, Christina N. Zdenek, Abhinandan Chowdhury, Abhinandan Chowdhury, Caroline F. B. Rodrigues, Caroline F. B. Rodrigues, Edgar Neri-Castro, Melisa Bénard-Valle, Alejandro Alagón, Bryan G. Fry   +10 more
doaj   +2 more sources

Inhibition of HIV-1 release by ADAM metalloproteinase inhibitors [PDF]

Frontiers in Microbiology
HIV-1 gp120 glycan binding to C-type lectin adhesion receptor L-selectin/CD62L on CD4 T cells facilitates viral attachment and entry. Paradoxically, the adhesion receptor impedes HIV-1 budding from infected T cells and the viral release requires the ...
Joanna Ireland, Jason Segura, Genbin Shi, Julianna Buchwald, Gwynne Roth, Thomas Juncheng Shen, Ruipeng Wang, Xinhua Ji, Elizabeth R. Fischer, Susan Moir, Tae-Wook Chun, Peter D. Sun   +11 more
doaj   +2 more sources

Crystal Structure of Human Cytochrome P450 2D6 with Prinomastat Bound [PDF]

Journal of Biological Chemistry, 2012
Human cytochrome P450 2D6 contributes to the metabolism of >15% of drugs used in clinical practice. This study determined the structure of P450 2D6 complexed with a substrate and potent inhibitor, prinomastat, to 2.85 Å resolution by x-ray crystallography.
Eric Johnson, Üzen Savas, C David Stout   +2 more
exaly   +3 more sources

Matrix Metalloproteinase Inhibition in Melanoma. [PDF]

Exp Dermatol
ABSTRACT Matrix metalloproteinases (MMPs) are involved in the degradation of the extracellular matrix (ECM) and are found to participate in all stages of tumour progression including modifying signalling pathways, regulating cytokines and promoting tumour growth, particularly by inducing angiogenesis and facilitating cancer spread.
Zhang E, Thakur V, Bedogni B.
europepmc   +2 more sources

Microsecond MD simulations of human CYP2D6 wild-type and five allelic variants reveal mechanistic insights on the function. [PDF]

PLoS ONE, 2018
Characterization of cytochrome P450 2D6 (CYP2D6) and the impact of the major identified allelic variants on the activity of one of the most dominating drug-metabolising enzymes is essential to increase drug safety and avoid adverse reactions. Microsecond
Charleen G Don, Martin Smieško
doaj   +2 more sources

Systematic Proteomic Characterization of EV-A71-Infected Mice Identifies Dynamic Molecular Changes and Therapeutic Targets. [PDF]

MedComm (2020)
Time‐resolved multi‐omics of EV‐A71‐infected BALB/c mice uncovered dynamic host responses, revealing rapid neutrophil extracellular traps (NETs) activation as a key event. Screened drugs (kinase inhibitors) suppressed viral replication in vitro and in vivo, suggesting the promise of targeting host phosphorylation networks as a viable antiviral strategy.
Peng W, Wang Q, Zhao B, Zhang L, Wu J, Wei X, Rong N, Wang Z, Liu K, Liu J, Yang J, Liu J.   +11 more
europepmc   +2 more sources

Prinomastat, a hydroxamate inhibitor of matrix metalloproteinases, has a complex effect on migration of breast carcinoma cells [PDF]

International Journal of Cancer, 2003
AbstractMembrane type‐1 matrix metalloproteinase (MT1‐MMP) and αvβ3 integrin have been directly implicated in tumor cell dissemination and metastasis. We have demonstrated that in the case of breast carcinoma MCF7 cells co‐expressing MT1‐MMP and αvβ3 integrin, the proteinase processes the pro‐αv integrin subunit, thus facilitating αvβ3 integrin ...
Alex Strongin
exaly   +3 more sources

Magnetic Resonance Imaging Detects Early Changes in Microvascular Permeability in Xenograft Tumors after Treatment with the Matrix Metalloprotease Inhibitor Prinomastat

Technology in Cancer Research and Treatment, 2004
Macromolecular contrast medium-enhanced magnetic resonance imaging was applied to monitor the effect of matrix metalloprotease (MMP) inhibition on microvascular characteristics of human breast cancers implanted in athymic rats. Twice-daily intraperitoneal administration of Prinomastat over 1.5 days induced significant declines in ...
Timothy Roberts, Laure S Fournier, Marlene Wiart   +2 more
exaly   +3 more sources