Results 31 to 40 of about 510 (116)

Keel venom: Rhabdophis subminiatus (red-necked keelback) venom pathophysiologically affects diverse blood clotting pathways. [PDF]

, 2022
Venoms are evolutionary novelties that have real-world implications due to their impact upon human health. However, relative to the abundant studies of elapid and viperid snake venoms, fewer investigations have been undertaken on those of rear-fanged ...
Casewell, Nick; id_orcid, Lewin, Matthew R., Chowdhury, Abhinandan, Fry, Bryan G., Carter, Rebecca W.   +4 more
core   +1 more source

The Effect of Prinomastat (AG3340), a Synthetic Inhibitor of Matrix Metalloproteinases, on Posttraumatic Proliferative Vitreoretinopathy

Ophthalmic Research, 2000
In a search for a pharmacologic adjuvant in the management of posttraumatic proliferative vitreoretinopathy (PVR), we investigated the effect of intravitreal injection of prinomastat (AG3340) on an experimental model. Posterior penetrating eye trauma was created in one eye each of 24 New Zealand white rabbits.
U, Ozerdem, B, Mach-Hofacre, K, Keefe, T, Pham, K, Soules, K, Appelt, W R, Freeman   +6 more
openaire   +2 more sources

Table_1_The Relative Efficacy of Chemically Diverse Small-Molecule Enzyme-Inhibitors Against Anticoagulant Activities of African Spitting Cobra (Naja Species) Venoms.xlsx

, 2021
African spitting cobras are unique among cobras for their potent anticoagulant venom activity arising from strong inhibition of Factor Xa. This anticoagulant effect is exerted by venom phospholipase A2 (Group I PLA2) toxins whose activity contributes to ...
Abhinandan Chowdhury (10287356), Bryan G. Fry (10287365), Rebecca Carter (791769), Christina N. Zdenek (10287353), Matthew R. Lewin (11532265)   +4 more
core   +1 more source

Time-dependent shedding of ß-dystroglycan by chloranil is blocked by the metalloproteinase inhibitor, prinomastat.

, 2013
Primary astrocytes were incubated with 25 µM chloranil for 4 or 7 h with or without addition of 15 nM or 30 nM prinomastat. Extracted proteins were loaded (30 µg/lane) and analyzed for ß-DG and AQP4 expression levels by western blot analysis.
Sarah Stevenson (355059), Geoffroy Noël (355057), Hakima Moukhles (355060)   +2 more
core   +1 more source

Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite

Journal of Tropical Medicine, Volume 2018, Issue 1, 2018., 2018
The World Health Organization (WHO) recently added snakebite envenoming to the priority list of Neglected Tropical Diseases (NTD). It is thought that ~75% of mortality following snakebite occurs outside the hospital setting, making the temporal gap between a bite and antivenom administration a major therapeutic challenge.
Tommaso C. Bulfone, Stephen P. Samuel, Philip E. Bickler, Matthew R. Lewin, Marcel Tanner   +4 more
wiley   +1 more source

Proteases Revisited: Roles and Therapeutic Implications in Fibrosis

Mediators of Inflammation, Volume 2017, Issue 1, 2017., 2017
Proteases target many substrates, triggering changes in distinct biological processes correlated with cell migration, EMT/EndMT and fibrosis. Extracellular protease activity, demonstrated by secreted and membrane‐bound protease forms, leads to ECM degradation, activation of other proteases (i.e., proteolysis of nonactive zymogens), decomposition of ...
Jakub Kryczka, Joanna Boncela, Christine-Maria Horejs   +2 more
wiley   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, Volume 293, Issue 13, Page 3717-3757, July 2026.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Targeting Angiogenesis for Controlling Neuroblastoma

Journal of Oncology, Volume 2012, Issue 1, 2012., 2012
Neuroblastoma, a progressive solid tumor in childhood, continues to be a clinical challenge. It is highly vascular, heterogeneous, and extracranial tumor that originates from neural crest. Angiogenesis, genetic abnormalities, and oncogene amplification are mainly responsible for malignant phenotype of this tumor.
Subhasree Roy Choudhury, Surajit Karmakar, Naren L. Banik, Swapan K. Ray, Arkadiusz Dudek   +4 more
wiley   +1 more source

Matrix Metalloproteinases in Neuropathic Pain and Migraine: Friends, Enemies, and Therapeutic Targets

Pain Research and Treatment, Volume 2012, Issue 1, 2012., 2012
Matrix metalloproteinases (MMPs) constitute a family of zinc‐dependent endopeptidases that mediate extracellular matrix turnover and associated processes, such as cell survival, growth, and differentiation. This paper discusses important functions of MMP in the normal and injured nervous system, focusing on the role played by these proteases in ...
Shaheen E. Lakhan, Mihaela Avramut, Jonathan O. Dostrovsky   +2 more
wiley   +1 more source

Vitamins as potent cancer treatments through regulating the activity and expression of MMP‐2 and MMP‐9

Bulletin of the Korean Chemical Society, Volume 47, Issue 6, Page 745-755, June 2026.
Vitamins could regulate both MMP‐2 and MMP‐9 expression and activity through transcriptional and MAPK signaling pathway modulation. This study highlights the potential of vitamins as low‐toxicity therapeutic or adjunct agents for targeting MMP‐mediated cancer progression. Abstract Matrix metalloproteinases (MMP‐2 and MMP‐9) are key regulators of cancer
Yen Thi Nguyen, Eungchan Kim, Ha Vy Thi Vo, Song Ja Kim, Namdoo Kim, Hyuck Jin Lee   +5 more
wiley   +1 more source